RT Journal Article T1 Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multicenter, three-armed randomized controlled trial conducted in primary care A1 Romero-Sanchiz, Pablo A1 Nogueira-Arjona, Raquel A1 García-Ruiz, Antonio J. A1 Luciano, Juan V. A1 Garcia Campayo, Javier A1 Gili, Margalida A1 Botella, Cristina A1 Baños, Rosa A1 Castro, Adoración A1 Lopez del Hoyo, Yolanda A1 Pérez Ara, Mª Ángeles A1 Modrego-Alarcón, Marta A1 Mayoral Cleries, Fermín K1 Depresión mental - Tratamiento - Ensayos clínicos AB The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program "Smiling is fun" with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective used in our analysis is societal. A sample of 296 depressed patients (mean age of 43.04 years; 76% female; BDI-II mean score = 22.37) from primary care services in four Spanish regions were randomized in the RCT. The complete case and intention-to-treat (ITT) perspectives wereused for the analyses. The results demonstrated that both Internet-based CBT interventions exhibited cost utility and cost effectiveness compared with a control group. The complete case analyses revealed an incremental cost-effectiveness ratio (ICER) of €-169.50 and an incremental cost-utility ratio (ICUR) of €-11389.66 for the TSG group and an ICER of €-104.63 and an ICUR of €-6380.86 for the LITG group. The ITT analyses found an ICER of €-98.37 and an ICUR of €-5160.40 for the TSG group and an ICER of €-9.91 and an ICUR of €496.72 for the LITG group. In summary, the results of this study indicate that the two Internet-based CBT interventions are appropriate from both economic and clinical perspectives for depressed patients in the Spanish primary care system. These interventions not only help patients to improve clinically but also generate societal savings. PB Public Library of Science YR 2017 FD 2017-02-27 LK https://hdl.handle.net/10630/30309 UL https://hdl.handle.net/10630/30309 LA eng NO Romero-Sanchiz P, Nogueira-Arjona R, GarcõÂa-Ruiz A, Luciano JV, GarcõÂa Campayo J, Gili M, et al. (2017) Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multi-center, three-armed randomized controlled trial conducted in primary care. PLoS ONE 12(2): e0172741. NO CC BY DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 20 ene 2026