RT Journal Article
T1 Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development
A1 Cano-Ballesteros, Sara
A1 Marín-Sedeño, Ernesto
A1 Palmquist-Gomes, Paul
A1 Guadix-Domínguez, Juan Antonio
A1 Pérez-Pomares, José María
K1 Sistema cardiovascular
K1 Endotelio
AB Fsp1 (a.k.a S100A4 or Metastatin) is an intracellular and secreted protein widely regarded as a fibroblast marker. Recent studies have nonetheless shown that Fsp1 is also expressed by other cell types, including small subsets of endothelial cells. Since no detailed and systematic description of Fsp1 spatio-temporal expression pattern in cardiac vascular cells is available in the literature, we have used a transgenic murine line (Fsp1-GFP) to study Fsp1 expression in the developing and postnatal cardiac vasculature and endocardium. Our work shows that Fsp1 is expressed in the endocardium and mesenchyme of atrioventricular valve primordia, as well as in some coronary venous and lymphatic endothelial cells. Fsp1 expression in cardiac venous and lymphatic endothelium is progressively restricted to the leaflets of cardiac venous and lymphatic valves. Our results suggest that Fsp1 could play a role in the development of atrioventricular valves and participate in the patterning and morphogenesis of cardiac venous and lymphatic vessel valves.
PB Wiley
YR 2020
FD 2020-09-13
LK https://hdl.handle.net/10630/45403
UL https://hdl.handle.net/10630/45403
LA eng
NO Cano-Ballesteros S, Palmquist-Gomes P, Marín-Sedeño E, Guadix JA, Pérez-Pomares JM. Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development. J Anat. 2021 Feb;238(2):508-514. doi: 10.1111/joa.13306. Epub 2020 Sep 13. PMID: 32920869; PMCID: PMC7812130.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026