RT Conference Proceedings
T1 Phosphorylation regulates cellulose biosynthesis regulation.
A1 Percio-Vargas, Francisco
A1 Toth, Ryan
A1 DeFalco, Thomas A.
A1 Persson, Staffan
A1 Zipfel, Cyril
A1 Amorim-Silva, Vitor
A1 Botella-Mesa, Miguel Ángel
K1 Celulosa
K1 Fisiología vegetal
K1 Plantas - Efectos del estrés
AB Plants comprise over 82% of all biomass on Earth, a third of which is cellulose, making it the mostabundant organic compound¹. Cellulose is also essential for plant development and defense againstmultiple stresses. But, despite its relevance, there remains much to be discovered about its biosyntheticregulation to improve crop’s tolerance to biotic and abiotic stresses.We have described the Tetratricopeptide Thioredoxin‐Like (TTL² proteins as regulators of the cellulosesynthase complex (CSC) under cellulose‐deficient conditions³. We found that TTLs are required tomaintain cellulose synthesis under salt stress by relocalising from the cytosol to the CSCs, promoting thepolymerization of microtubules to form a stress‐resilient cortical microtubule array, and interacting withthe CSCs to stabilize them at the plasma membrane.We are currently investigating how TTLs are targeted to the CSCs. We have found that TTL3 is a substratefor a kinase that when mutated show cellulose‐defective phenotypes under stresses that affect cell wallintegrity. We are currently analysing how the CSCs and microtubules behave under abiotic stress inmutants for this kinase. This will provide new insights into how changes in phosphorylation statusregulate the activity and dynamic localization of these proteins.
YR 2023
FD 2023
LK https://hdl.handle.net/10630/27285
UL https://hdl.handle.net/10630/27285
LA eng
NO This work was funded by the Spanish Ministry for Science and Innovation(PID2020-114419RB-I00MCIN/AEI/10.13039/501100011033 ) to MAB. The AndalusianResearch Plan co-financed by the European Union (PAIDI 2020-PY20_00084 and UMA20-FEDERJA-023) to MAB. FP was supported byFPU19/02219 fellowships and EMBO Scientific Exchange Grant 10026 and VASwas supported by an Emerging Investigator research project (UMA20-FEDERJA-007) and co-financed by the “Programa Operativo FEDER 2014-2020” and bythe “Consejería de Economía y Conocimiento de la Junta de Andalucía”.Funding from the University of Zürich, and the Swiss National Science Foundationgrants no. 31003A_182625 and no. 310030_212382 (to CZ). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026