RT Journal Article
T1 Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
A1 Medina-Cáliz, Inmaculada
A1 García-Cortés, Miren
A1 González-Jiménez, Andrés
A1 Cabello-Porras, María Rosario
A1 Robles-Díaz, María Mercedes
A1 Sanabria-Cabrera, Judith Adriana
A1 Sanjuan-Jimenez, Rocio
A1 Ortega-Alonso, Aida
A1 García-Muñoz, Beatriz
A1 Moreno, Inmaculada
A1 Jiménez-Pérez, Miguel
A1 Fernández, M. Carmen
A1 Ginés, Pere
A1 Prieto, Martin
A1 Conde, Isabel
A1 Hallal, Hacibe
A1 Soriano, German
A1 Roman, Eva
A1 Castiella, Agustin
A1 Blanco-Reina, Encarnación
A1 Montes, Maria R
A1 Quiros-Cano, Marta
A1 Martín-Reyes, Flores
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
K1 Hígado -  Efectos de los medicamentos
AB There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients with herbal and dietary supplement-associated liver injury reported to the Spanish DILI registry from 1994 through 2016.We used analysis of variance to compare these data with those from cases of liver injury induced by conventional drugs or anabolic androgenic steroid-containing products.Herbal and dietary supplements were responsible for 4% of the 856 DILI cases in the registry;20 cases of DILI were caused by anabolic androgenic steroids.Patients with herbal and dietary supplement-induced liver injury were a mean age of 48 years and 63% were female;they presented a mean level of alanine aminotransferase 37-fold the upper limit of normal, 28% had hypersensitivity features, and 78% had jaundice.Herbal and dietary supplement-induced liver injury progressed to acute liver failure in 6% of patients, compared with none of the cases of anabolic androgenic steroid-induced injury and 4% of cases of conventional drugs.Liver injury after repeat exposure to the same product that caused the first DILI episode occurred in 9% of patients with herbal and dietary supplement-induced liver injury vs none of the patients with anabolic androgenic steroid-induced injury and 6% of patients with liver injury from conventional drugs.In an analysis of cases of herbal and dietary supplement-induced liver injury in Spain, we found cases to be more frequent among young women than older patients or men, and to associate with hepatocellular injury and high levels of transaminases.Herbal and dietary supplement-induced liver injury is more severe than other types of DILI and re-exposure is more likely.Increasing awareness of the hepatoxic effects of herbal and dietary supplements could help physicians make earlier diagnoses and reduce the risk of serious liver damage.
PB Elsevier
YR 2018
FD 2018-01
LK https://hdl.handle.net/10630/29762
UL https://hdl.handle.net/10630/29762
LA eng
NO Medina-Caliz I, Garcia-Cortes M, Gonzalez-Jimenez A, Cabello MR, Robles-Diaz M, Sanabria-Cabrera J, Sanjuan-Jimenez R, Ortega-Alonso A, García-Muñoz B, Moreno I, Jimenez-Perez M, Fernandez MC, Ginés P, Prieto M, Conde I, Hallal H, Soriano G, Roman E, Castiella A, Blanco-Reina E, Montes MR, Quiros-Cano M, Martin-Reyes F, Lucena MI, Andrade RJ; Spanish DILI Registry. Herbal and Dietary Supplement-Induced Liver Injuries in the Spanish DILI Registry. Clin Gastroenterol Hepatol. 2018 Sep;16(9):1495-1502. doi: 10.1016/j.cgh.2017.12.051.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026