RT Journal Article
T1 The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).
A1 Martín-Sierra, Carmen
A1 Bravo-Romero, María José
A1 Saez, Maria Eugenia
A1 De Rojas, Itziar
A1 Santos, Marta
A1 Martín-Carmona, Jesica
A1 Corma-Gómez, Anaïs
A1 González-Serna, Alejandro
A1 Royo-Sánchez-Palencia, José Luis
A1 Pineda, Juan A.
A1 Rivero, Antonio
A1 Rivero-Juárez, Antonio
A1 Macías, Juan
A1 Real-Navarrete, Luis Miguel
K1 Virus de la hepatitis C
AB Background & aimsIt has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly associated with the lack of active infection and seroconversion after exposition to hepatitis C virus (HCV).ObjectiveTo determine whether these KIR-HLA combinations are relevant factors involved in that phenotype.Patients and methodsIn this retrospective case-control study, genotype data from a genome-wide association study previously performed on low susceptibility to HCV-infection carried out on 27 high-risk HCV-seronegative (HRSN) individuals and 743 chronically infected (CI) subjects were used. HLA alleles were imputed using R package HIBAG v1.2223 and KIR genotypes were imputed using the online resource KIR*IMP v1.2.0.ResultsIt was possible to successfully impute at least one KIR-HLA genotype combination previously associated with the lack of infection and seroconversion after exposition to HCV in a total of 23 (85.2%) HRSN individuals and in 650 (87.5%) CI subjects. No KIR-HLA genotype combination analyzed was related to the HRSN condition.ConclusionsOur results suggest that those KIR-HLA genotype combinations are not relevant factors involved in the lack of infection and seroconversion after exposition to HCV. More studies will be needed to completely understand this phenotype.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/10630/37186
UL https://hdl.handle.net/10630/37186
LA eng
NO Carmen Martín-Sierra, María José Bravo, María Eugenia Sáez, Itziar De Rojas, Marta Santos, Jesica Martín-Carmona, Anaïs Corma-Gómez, Alejandro González-Serna, José Luis Royo, Juan A. Pineda, Antonio Rivero, Antonio Rivero-Juárez, Juan Macías, Luis Miguel Real, The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study), Antiviral Research, Volume 222, 2024, 105795, ISSN 0166-3542, https://doi.org/10.1016/j.antiviral.2024.105795. (https://www.sciencedirect.com/science/article/pii/S0166354224000032)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 27 feb 2026