RT Journal Article
T1 Low serum iron levels and risk of cardiovascular disease in high risk elderly population: Nested caseecontrol study in the PREvenci on con DIeta MEDiterr anea (PREDIMED) trial
A1 Gutiérrez-Bedmar, Mario
A1 Olmedo, Pablo
A1 Gil, Fernando
A1 Ruiz-Canela, Miguel
A1 Martínez González, Miguel Ángel
A1 Salas-Salvadó, Jordi
A1 Babio, Nancy
A1 Fito, Montserrat
A1 del Val, José L.
A1 Corella, Dolores
A1 Sorlí, José V.
A1 Ros, Emilio
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Lapetra, José
A1 Arós, Fernando
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Gómez-Gracia, Enrique
K1 Corazón - Enfermedades
AB Epidemiological data on iron status and cardiovascular disease (CVD) are still controversial. The aim of this study was to determine whether low serum iron (SI) levels are associated with an increased odds of first CVD event in a population at high cardiovascular risk.Methods: Case-control study design nested within the "PREvención con DIeta MEDiterránea"  (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke or cardiovascular death) during follow-up period (2003-2010) were matched by sex, age and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. Inductively coupled plasma mass spectrometry analysis was used to determine SI levels. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. Multivariable-adjusted odds ratios (ORs) of CVD were calculated with conditional logistic regression.Results: Mean SI levels were higher in men than in women (1224.0 μg/L vs. 1093.8 μg/L; p < 0.001). Among women, but not in men, the mean SI concentration was lower in cases than in controls (1008.5 μg/L vs. 1132.9 μg/L; p = 0.030). There was a gradual decrease in the multivariable-adjusted ORs of CVD with increasing SI levels (highest vs. lowest quartile: OR = 0.55, 95% CI: 0.32-0.93; ptrend = 0.020). This inverse relationship was more pronounced among women (highest vs. lowest quartile: OR = 0.15, 95% CI: 0.03-0.69; ptrend = 0.011).Conclusions: The present findings are consistent with previously reported inverse associations between SI and CVD. SI levels as an independent marker of short-term cardiovascular risk may be useful for risk assessment in older populations.
PB Elsevier
YR 2021
FD 2021-02
LK https://hdl.handle.net/10630/44782
UL https://hdl.handle.net/10630/44782
LA eng
NO Gutierrez-Bedmar M, Olmedo P, Gil F, Ruiz-Canela M, Martínez-González MA, Salas-Salvadó J, Babio N, Fito M, Del Val JL, Corella D, Sorli JV, Ros E, Fiol M, Estruch R, Lapetra J, Arós F, Serra-Majem L, Pintó X, Gomez-Gracia E. Low serum iron levels and risk of cardiovascular disease in high risk elderly population: Nested case-control study in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Clin Nutr. 2021 Feb;40(2):496-504. doi: 10.1016/j.clnu.2020.05.044. Epub 2020 Jun 12. PMID: 32591250.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026