RT Journal Article
T1 Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies
A1 Espinosa García, Elena María
A1 Arroyo Varela, Macarena
A1 Larrosa-Jiménez, Rafael
A1 Gómez‑Maldonado, Josefa
A1 Cobo Dols, Manuel Ángel
A1 Claros-Díaz, Manuel Gonzalo
A1 Bautista-Moreno, Rocío
K1 Ácido ribonucleico
K1 Cáncer - Investigación
K1 Oncología
AB Lung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis using liquid biopsies was expanded. A total of 30 samples of LC were analyzed to define potential miRNA biomarkers in liquid biopsies for LC. The biomarkers have been identified in interaction networks miRNA–mRNA. The potential biomarkers have been then validated in large cohorts. A total of 15 candidate miRNAs, that regulate the repression of 30 mRNAs, have been identified as a specific functional interaction network for squamous carcinoma, while the specific functional interaction network of adenocarcinoma consists of four candidate miRNAs that seem to handle the repression of five mRNA. Inspection of expression levels in larger cohorts validates the usefulness of the 11 candidates as biomarkers in liquid biopsies. The 11 candidate miRNAs found could be utilized to form diagnostic predictive biomarkers for LC in liquid biopsies.
PB Springer Nature
YR 2022
FD 2022-10-12
LK https://hdl.handle.net/10630/26298
UL https://hdl.handle.net/10630/26298
LA eng
NO Espinosa Garcia, E., Arroyo Varela, M., Larrosa Jimenez, R., Gomez-Maldonado, J., Cobo Dols, M. A., Claros, M. G., & Bautista Moreno, R. (2023). Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies. Clinical and Translational Oncology, 25(3), 643-652.
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding for open access charge: Universidad de Málaga / CBUA. This work was funded by the Neumosur grant number 5/2017 and SEPAR grant number 697/2018
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 5 mar 2026