RT Journal Article
T1 Transcriptomic Profiles of senegalese sole infected With nervous necrosis Virus reassortants Presenting Different Degree of Virulence.
A1 Labella Vera, Alejandro Manuel
A1 García-Rosado, Esther
A1 Bandin, Isabel
A1 Dopazo, Carlos
A1 Castro-López, María Dolores
A1 Alonso-Sánchez, María del Carmen
A1 Borrego-García, Juan José
K1 Virus con ARN
K1 Lenguados
AB Betanodaviruses [nervous necrosis virus (NNV)] are the causative agent of the viral encephalopathyand retinopathy, a disease that affects cultured Senegalese sole (Solea senegalensis).NNV reassortants, combining genomic segments from redspotted grouper nervous necrosisvirus (RGNNV) and striped jack nervous necrosis virus (SJNNV) genotypes, have been previouslyisolated from several fish species. The wild-type reassortant wSs160.03, isolated fromSenegalese sole, has been proven to be more virulent to sole than the parental genotypes(RGNNV and SJNNV), causing 100% mortality. Mutations at amino acids 247 (serine toalanine) and 270 (serine to asparagine) in the wSs160.03 capsid protein have allowed us toobtain a mutant reassortant (rSs160.03247+270), which provokes a 40% mortality decrease.In this study, the RNA-Seq technology has been used to comparatively analyze Senegalesesole transcriptomes in two organs (head kidney and eye/brain) after infection with wild-typeand mutant strains.
PB Frontiers
YR 2018
FD 2018-07-17
LK https://hdl.handle.net/10630/34424
UL https://hdl.handle.net/10630/34424
LA eng
NO Labella AM, Garcia-Rosado E, Bandín I, Dopazo CP, Castro D, Alonso MC and Borrego JJ (2018) Transcriptomic Profiles of Senegalese Sole Infected With Nervous Necrosis Virus Reassortants Presenting Different Degree of Virulence. Front. Immunol. 9:1626. doi: 10.3389/fimmu.2018.01626
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026