RT Journal Article
T1 Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases
A1 Berni Canani, Roberto
A1 Caminati, Marco
A1 Carucci, Laura
A1 Eguiluz-Gracia, Ibón
K1 Alergia
AB The  epithelial  barriers  of  the  skin,  gut,  and  respiratory  tract  are  critical  interfaces  between the environment and the host, and they orchestrate both homeostatic and pathogenic  immune  responses.  The  mechanisms  underlying  epithelial  barrier  dys-function  in  allergic  and  inflammatory  conditions,  such  as  atopic  dermatitis,  food  al-lergy,  eosinophilic  oesophagitis,  allergic  rhinitis,  chronic  rhinosinusitis,  and  asthma,  are  complex  and  influenced  by  the  exposome,  microbiome,  individual  genetics,  and  epigenetics. Here, we review the role of the epithelial barriers of the skin, digestive tract, and airways in maintaining homeostasis, how they influence the occurrence and progression  of  allergic  and  inflammatory  conditions,  how  current  treatments  target  the epithelium to improve symptoms of these disorders, and what the unmet needs are in the identification and treatment of epithelial disorders.
PB Wiley
YR 2024
FD 2024-03-04
LK https://hdl.handle.net/10630/30858
UL https://hdl.handle.net/10630/30858
LA eng
NO Canani, R.B., Caminati, M., Carucci, L, & Eguiluz-Gracia, I. (2024). Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases. Allergy, 1-16. DOI: 10.1111/all.16092
NO Funding for open access charge: Universidad de Málaga/CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026