RT Journal Article
T1 Brain Glucose-Sensing Mechanism and Energy Homeostasis.
A1 López-Gambero, Antonio Jesús
A1 Martínez, Fernando
A1 Salazar, Katty
A1 Cifuentes-Rueda, Manuel
A1 Nualart, Francisco
K1 Glucosa - Síntesis
AB The metabolic and energy state of the organism depends largely on the availability of substrates, such as glucose for ATP production, necessary for maintaining physiological functions. Deregulation in glucose levels leads to the appearance of pathological signs that result in failures in the cardiovascular system and various diseases, such as diabetes, obesity, nephropathy, and neuropathy. Particularly, the brain relies on glucose as fuel for the normal development of neuronal activity. Regions adjacent to the cerebral ventricles, such as the hypothalamus and brainstem, exercise central control in energy homeostasis. These centers house nuclei of neurons whose excitatory activity is sensitive to changes in glucose levels. Determining the different detection mechanisms, the phenotype of neurosecretion, and neural connections involving glucose-sensitive neurons is essential to understanding the response to hypoglycemia through modulation of food intake, thermogenesis, and activation of sympathetic and parasympathetic branches, inducing glucagon and epinephrine secretion and other hypothalamic-pituitary axis-dependent counterregulatory hormones, such as glucocorticoids and growth hormone. The aim of this review focuses on integrating the current understanding of various glucose-sensing mechanisms described in the brain, thereby establishing a relationship between neuroanatomy and control of physiological processes involved in both metabolic and energy balance. This will advance the understanding of increasingly prevalent diseases in the modern world, especially diabetes, and emphasize patterns that regulate and stimulate intake, thermogenesis, and the overall synergistic effect of the neuroendocrine system.
PB Springer Nature
YR 2019
FD 2019
LK https://hdl.handle.net/10630/35860
UL https://hdl.handle.net/10630/35860
LA eng
NO López-Gambero AJ, Martínez F, Salazar K, Cifuentes M, Nualart F. Brain Glucose-Sensing Mechanism and Energy Homeostasis. Mol Neurobiol. 2019 Feb;56(2):769-796. doi: 10.1007/s12035-018-1099-4. Epub 2018 May 24. PMID: 29796992.
NO Política de acceso abierto tomada de: https://openpolicyfinder.jisc.ac.uk/id/publication/13030
NO FONDECYT Initiation into Research grant Fondecyt 11150678 (Fernando MartÍnez), Fondecyt 11140405 (Katterine Salazar), Fondecyt 1181243 (Francisco Nualart), and a CONICYT PIA ECM-12 grant (Francisco Nualart).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026