RT Journal Article
T1 Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions.
A1 Rivera-González, Patricia
A1 Romero-Zerbo, Silvana Yanina
A1 Pavón-Morón, Francisco Javier
A1 Serrano, Antonia
A1 López-Ávalos, María  Dolores
A1 Cifuentes-Rueda, Manuel
A1 Mateos-Grondona, Jesús
A1 Bermúdez-Silva, Francisco Javier
A1 Fernández-Llebrez, Pedro
A1 Rodriguez de Fonseca, Fernando
A1 Suárez-Pérez, Juan
A1 Pérez-Martín, Margarita
K1 Obesidad
K1 Enfermedades de origen nutricional
K1 Hipocampo (Cerebro)
K1 Hipotálamo
K1 Neurobiología del desarrollo
K1 Modelos animales en investigación
AB Endocannabinoid signalling participates in the control of neurogenesis, especially after brain insults. Obesity may explain alterations in physiology affecting neurogenesis, although it is unclear whether cannabinoid signalling may modulate neural proliferation in obese animals. Here we analyse the impact of obesity by using two approaches, a high-fat diet (HFD, 60% fat) and a standard/low-fat diet (STD, 10% fat), and the response to a subchronic treatment with the cannabinoid receptor type 1 (CB1) inverse agonist AM251 (3 mg/kg) on cell proliferation of two relevant neurogenic regions, namely the subventricular zone in the striatal wall of the lateral ventricle (SVZ) and the subgranular zone of the dentate gyrus (SGZ), and also in the hypothalamus given its role in energy metabolism. We found evidence of an interaction between diet-induced obesity and CB1 signalling in the regulation of cell proliferation. AM251 reduced caloric intake and body weight in obese rats, as well as corrected plasma levels of cholesterol and triglycerides. AM251 is shown, for the first time, to modulate cell proliferation in HFD-obese rats only. We observed an increase in the number of 5-bromo-2-deoxyuridine-labelled (BrdU+) cells in the SGZ, but a decrease in the number of BrdU+ cells in the SVZ and the hypothalamus of AM251-treated HFD rats. These BrdU+ cells expressed the neuron-specific βIII-tubulin. These results suggest that obesity may impact cell proliferation in the brain selectively, and provide support for a role of CB1 signalling regulation of neurogenesis in response to obesity.
PB Wiley
YR 2011
FD 2011-05
LK https://hdl.handle.net/10630/40322
UL https://hdl.handle.net/10630/40322
LA eng
NO Rivera, P., Romero-Zerbo, Y., Pavón, F. J., Serrano, A., López-Ávalos, D., Cifuentes, M., Grondona, M., Bermúdez-Silva, J., Fernández-Llebrez, P., Suárez, J., & Pérez-Martín, M. (2011). Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions. European Journal of Neuroscience, 33(9), 1577-1586. https://doi.org/10.1111/j.1460-9568.2011.07650.x
NO https://openpolicyfinder.jisc.ac.uk/id/publication/6992
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026