RT Journal Article
T1 A metagenome-wide association study of HIV disease progression in HIV controllers.
A1 Real-Navarrete, Luis Miguel
A1 Saéz, María E
A1 Corma-Gómez, Anaïs
A1 González-Pérez, Antonio
A1 Thorball, Christian
A1 Ruiz, Rocío
A1 Jiménez-León, María Reyes
A1 González-Serna, Alejandro
A1 Gasca-Capote, Carmen
A1 Bravo-Romero, María José
A1 Royo-Sánchez-Palencia, José Luis
A1 Pérez-Gómez, Alberto
A1 Camacho-Sojo, María Inés
A1 Gallego, Isabel
A1 Joana, Vitalle
A1 Bachiller, Sara
A1 Gutierrez-Valencia, Alicia
A1 Vidal, Francisco
A1 Fellay, Jacques
A1 Lichterfeld, Mathias
A1 Ruiz-Mateos, Ezequiel
K1 Virus del SIDA
AB Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 and 119 from the International HIV controllers Study Cohort and the Swiss HIV Cohort Study, respectively. No SNP or gene was associated with the long-term non-progressor HIV spontaneous control phenotype in the individual GWAS or in the meta-analysis. However, SNPs previously associated with natural HIV control linked to HLA-B (rs2395029 [p = 0.005; OR = 1.70], rs59440261 [p = 0.003; OR = 1.78]), MICA (rs112243036 [p = 0.011; OR = 1.45]), and PSORS1C1 loci (rs3815087 [p = 0.017; OR = 1.39]) showed nominal association with this phenotype. Genetic factors associated with the long-term HIV controllers without risk of immunologic progression are those previously related to the overall HIV controller phenotype.
PB Elsevier
YR 2023
FD 2023
LK https://hdl.handle.net/10630/37184
UL https://hdl.handle.net/10630/37184
LA eng
NO Luis Miguel Real, María E. Sáez, Anais Corma-Gómez, Antonio Gonzalez-Pérez, Christian Thorball, Rocío Ruiz, María Reyes Jimenez-Leon, Alejandro Gonzalez-Serna, Carmen Gasca-Capote, María José Bravo, José Luis Royo, Alberto Perez-Gomez, María Inés Camacho-Sojo, Isabel Gallego, Joana Vitalle, Sara Bachiller, Alicia Gutierrez-Valencia, Francisco Vidal, Jacques Fellay, Mathias Lichterfeld, Ezequiel Ruiz-Mateos, A metagenome-wide association study of HIV disease progression in HIV controllers, iScience, Volume 26, Issue 7, 2023, 107214, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.107214. (https://www.sciencedirect.com/science/article/pii/S2589004223012919)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026