RT Journal Article
T1 Timeline of Intestinal Adaptation After Malabsortive Surgery: Effect of Luminal Nutrients, Biliopancreatic Secretion, and Glutamine Supplementation
T2 Cronologia de la adaptación intestinal tras cirugía de Malabsortiva: Efecto de los nutrientes luminales, la secretación de Biliopancreático y la suplementación con glutamina
A1 Martínez-Moreno, José Manuel
A1 Reyes-Ortiz, Alexander
A1 Lage Sanchez, Jose María
A1 Sánchez-Gallegos, María Pilar
A1 García-Caballero, Manuel
K1 Obesidad - Cirugía
AB Three types of surgery were performed using a porcine model: biliopancreatic bypass (BPBP), massive (75%) short bowel resection as the positive control, and a sham operation (transection) as the negative control. We measured the height and width of intestinal villi, histidine decarboxylase (HDC) activity, and amount of HDC messenger RNA (mRNA) (standard diet or a diet supplemented with glutamine).An increase in HDC activity and mRNA expression was observed in the BPBP group. This increase coincided with an increase in the height and width of the intestinal villi. The increase in villus height was observed immediately after surgery and peaked at 2 weeks. Levels remained higher than those observed in sham-operated pigs for a further 4 weeks.The intestinal adaptation process in animals that underwent BPBP was less intense than in those that underwent massive short bowel resection and more intense than in those that underwent transection only. Supplementation with glutamine did not improve any of the parameters studied, although it did appear to accelerate the adaptive process.
PB Springer
YR 2017
FD 2017
LK https://hdl.handle.net/10630/36308
UL https://hdl.handle.net/10630/36308
LA eng
NO Martínez Moreno, J.M., Reyes-Ortiz, A., Lage Sánchez, J.M. et al. Timeline of Intestinal Adaptation After Malabsortive Surgery: Effect of Luminal Nutrients, Biliopancreatic Secretion, and Glutamine Supplementation. OBES SURG 27, 3133–3141 (2017). https://doi.org/10.1007/s11695-017-2754-y
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026