RT Journal Article
T1 Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins.
A1 Murciano, Carmen
A1 Cazorla-Vázquez, Salvador
A1 Gutiérrez, Javier
A1 Hijano, Juan Antonio
A1 Ruiz-Sánchez, Josefa
A1 Mesa-Almagro, Laura
A1 Martín-Reyes, Flores
A1 Fernández-Duarte, Tahía Diana
A1 Marí-Beffa, Manuel
K1 Receptores celulares
K1 Factores de crecimiento
K1 Aletas - Regeneración
K1 Biología del desarrollo
AB The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signallingprocesses which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the finpattern along the proximodistal axis brings with it several well-known developmental regulators, themechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing thezebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species,we hypothesized a connection between specific inter-ray regulatory mechanisms and the morphologicalvariability of inter-ray membranes found in nature. To tackle these issues, both cellular and molecularapproaches have been adopted and our results suggest the existence of two distinguishable inter-ray areas inthe zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cellmembrane potassium channel kcnk5b, the fibroblast growth factor receptor 1 and the sonic hedgehogpathway to the control of several cell functions involved in inter-ray wound healing or dorsoventralregeneration of the zebrafish caudal fin. This ray-dependent regulation controls cell migration, cell-typepatterning and gene expression. The possibility that modifications of these mechanisms are responsible forphenotypic variations found in euteleostean species, is discussed.
PB Wiley
YR 2018
FD 2018-02-14
LK https://hdl.handle.net/10630/40237
UL https://hdl.handle.net/10630/40237
LA eng
NO Murciano, C., Cazorla-Vázquez, S., Gutiérrez, J., Hijano, J. A., Ruiz-Sánchez, J., Mesa-Almagro, L., Martín-Reyes, F., Fernández, T. D., & Marí-Beffa, M. (2018). Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins. Journal of anatomy, 232(5), 783–805. https://doi.org/10.1111/joa.12785
NO https://openpolicyfinder.jisc.ac.uk/id/publication/6894
NO Ministerio de Educación y Ciencia
NO Ministerio de Ciencia y Tecnología
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026