RT Journal Article
T1 In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells
A1 Palmquist-Gomes, Paul
A1 Marín-Sedeño, Ernesto
A1 Ruiz Villalba, Adrián
A1 Rico Llanos, Gustavo Adolfo
A1 Pérez-Pomares, José María
A1 Guadix-Domínguez, Juan Antonio
K1 Corazón - Embriología
K1 Tejidos (Biología)
K1 Cartílagos
K1 Células cardiacas
AB The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli.
PB MDPI
YR 2022
FD 2022-03-25
LK https://hdl.handle.net/10630/45399
UL https://hdl.handle.net/10630/45399
LA eng
NO Palmquist-Gomes P, Marín-Sedeño E, Ruiz-Villalba A, Rico-Llanos GA, Pérez-Pomares JM, Guadix JA. In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells. Int J Mol Sci. 2022 Mar 25;23(7):3614. doi: 10.3390/ijms23073614. PMID: 35408974; PMCID: PMC8999123.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 2 mar 2026