RT Journal Article
T1 Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
A1 Sampedro-Piquero, Patricia
A1 Moreno-Fernández, Román D.
A1 Mañas-Padilla, María del Carmen
A1 Gil Rodríguez, Sara
A1 Gavito, Ana L.
A1 Pavón-Morón, Francisco Javier
A1 Pedraza-Benítez, María del Carmen
A1 García-Fernández, María Inmaculada
A1 Ladrón de Guevara-Miranda, David
A1 Santín-Núñez, Luis Javier
A1 Castilla-Ortega, María Estela
K1 Neuroplasticidad
K1 Memoria
AB (AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN outcome. Currently, little is known regarding the effect of appetitively-motivated training on AHN. Hence we studied how spatial learning to find food rewards in a hole-board maze modulates AHN (cell proliferation and immature neurons) and AHN-related hippocampal neuroplasticity markers (BDNF, IGF-II and CREB phosphorylation) in mice. The ‘Trained’ mice were tested for both spatial reference and working memory and compared to ‘Pseudotrained’ mice (exposed to different baited holes in each session, thus avoiding the reference memory component of the task) and ‘Control’ mice (exposed to the maze without rewards). In contrast to Pseudotrained and Control mice, the number of proliferating hippocampal cells were reduced in Trained mice, but they notably increased their population of immature neurons assessed by immunohistochemistry. This evidence shows that hole-board spatial reference learning diminishes cell proliferation in favor of enhancing young neurons’ survival. Interestingly, the enhanced AHN in the Trained mice (specifically in the suprapyramidal blade) positively correlated with their reference memory performance, but not with their working memory. Furthermore, the Trained animals increased the hippocampal protein expression of all the neuroplasticity markers analyzed by western blot. Results show that the appetitively-motivated hole- board task is a useful paradigm to potentiate and/or investigate AHN and hippocampal plasticity minimizing aversive variables such as fear or stress.
PB Elsevier
YR 2018
FD 2018
LK https://hdl.handle.net/10630/23843
UL https://hdl.handle.net/10630/23843
LA eng
NO Sampedro-Piquero P, Moreno-Fernández RD, Mañas-Padilla MC, Gil-Rodríguez S, Gavito AL, Pavón FJ, lm.2018.03.023. Epub 201Pedraza C, García-Fernández M, Ladrón de Guevara-Miranda D, Santín LJ, Castilla-Ortega E. Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiol Learn Mem. 2018 May;151:35-42. doi: 10.1016/j.n8 Mar 31. PMID: 29608953.
NO Author manuscript
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (Agencia Estatal de Investigación) co-funded by the European Research Development Fund -AEI/FEDER, UE- (PSI2015-73156-JIN to E.C.O.; PSI2013-44901-P to L.J.S. and C.P.; PSI2017-82604R to L.J.S.), from ‘Junta deAndalucía’ SEJ1863 to C.P. and from University of Málaga (Plan Propio 2017 – ‘Ayudas para proyectos puente’) to M.G.F and (Plan Propio 2017-‘Ayudas para proyectos dirigidos por jóvenes investigadores’, PPIT.UMA.B1.2017/38) to P.S.P.Author P.S.P. holds a ‘Juan de la Cierva-formación‘ grant from the Spanish Ministry of Economy, Industry and Competitiveness (code: FJCI-2015-23925) and a ‘D.3. Estancia de investigadores de reconocido prestigio en la UMA‘ grant from the University of Málaga. Authors R.D.M.F. and D.L.G.M. hold ‘FPU’ grants from the Spanish Ministry of Education, Culture and Sports (code: FPU14-01610 and FPU13/04819, respectively). Author F.J.P. holds a ‘Miguel Servet’ grant (code: CP14/00212) from the National System of Health-Instituto de Salud Carlos-III co-funded by FEDER, UE. Author E.C-O holds a ‘Jóvenes Investigadores’ grant (code: PSI2015-73156-JIN) from the Spanish Agencia Estatal de Investigación co-funded by AEI/FEDER, UE.The authors acknowledge CIBERTEC for their technical
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