RT Journal Article
T1 Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions
A1 Narváez-Peláez, Manuel
A1 Millón-Peñuela, Carmelo
A1 Borroto Escuela, Dasiel Óscar
A1 Flores-Burgess, Antonio
A1 Santín-Núñez, Luis Javier
A1 Parrado-Romero, Concepción
A1 Gago-Calderón, Belén
A1 Puigcerver-Martínez, Araceli
A1 Fuxe, Kjell
A1 Narváez-Bueno, José Ángel
A1 Díaz-Cabiale, Zaida
K1 Neuropéptidos
K1 Angustia
K1 Depresión mental
AB Galanin (GAL) and Neuropeptide Y (NPY) are neuropeptides involved in behaviors associated with anxiety. Both neuropeptides interact in several central functions. However, the potential behavioral and cellular interactionsbetween them in anxiety are unknown. GAL was found to act through GAL receptor 2 (GALR2) to enhance NPYY1 receptor (NPYY1R) mediated anxiolytic behaviors in rats. Using receptor autoradiography, c-fos expression and in situ proximity ligation assay, the medial paracapsular intercalated nuclei of the amygdala were determined to be a key area in the interaction probablyinvolving the formation of GALR2/NPYY1R heteroreceptor complexes. In cell cultures co-stimulation of GALR2 and NPYY1R induced changes in the functions of these receptors. The changes involved a potentiation of thedecrease in the phosphorylation of CREB induced by NPYY1R and a delay in the internalization of NPYY1R. These results indicate that GALR2/NPYY1R interactions can provide a novel integrative amygdaloid mechanism in anxiety.
PB Springer Nature
SN 1863-2653
YR 2014
FD 2014-05-20
LK https://hdl.handle.net/10630/33192
UL https://hdl.handle.net/10630/33192
LA eng
NO Narváez, M., Millón, C., Borroto-Escuela, D. et al. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions. Brain Struct Funct 220, 2289–2301 (2015).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026