RT Journal Article
T1 Effectiveness of different exercise modalities in Heart Failure with preserved Ejection Fraction. A systematic review with network meta-analysis
A1 Henríquez-Jurado, Juan Manuel
A1 Fuentes-Abolafio, Iván José
A1 García-Conejo, Celia
A1 Cuesta-Vargas, Antonio
K1 Fisioterapia
K1 Insuficiencia cardíaca
K1 Ejercicio físico
K1 Meta-análisis
AB Aims: The study aimed to compare the effectiveness of various exercise modalities in improving exercise performance, echocardiographic parameters and quality of life in patients with heart failure with preserved ejection fraction. Methods: A systematic review over 7 databases was conducted up to May 2024. Randomised controlled trials analysing the efficacy of any exercise modality in isolation were included. For each variable, a Frequentist and Bayesian Network Meta-Analysis were conducted. Mean differences between groups with 95% confidence and credible intervals were calculated for each outcome. Quality of the evidence was assessed with GRADE, being very low for every outcome. Results: 12 RCTs were included, providing data from 602 patients. The Frequentist model showed effectiveness for: CT on peak VO2, VO2 at ventilatory threshold (VT) and E/´e ratio; high-intensity interval training (HIIT) on peak VO2, VE/VCO2 slope, cardiopulmonary exercise testing (CPET) time and E/´ e; inspiratory muscle training (IMT) on peak VO2, VE/VCO2 slope, RER and 6-minute walking test (6MWT); moderate-intensity aerobic training (MIAT) on peak VO2, CPET time, peak power output (PPO), 6MWT and E/´ e ratio; and Tai Chi on peak VO2. The Bayesian model only supports these findings for CT on peak VO2; IMT on peak VO2; MIAT on CPET time, PPO, and 6MWT; and Tai Chi on peak VO2. Conclusions: Considering both models, the evidence, albeit of very low quality, supports the effectiveness of various exercise modalities except HIIT in exercise capacity parameters (peak VO2, CPET time, PPO and 6MWT). There is an effect over VO2 at VT, VE/VCO2 slope, RER, LVEF, E/´ e and MLHFQ, but only supported by the Frequentist model. PROSPERO registration number: CRD42024560028
PB Elsevier
SN 1413-3555
YR 2026
FD 2026
LK https://hdl.handle.net/10630/46418
UL https://hdl.handle.net/10630/46418
LA eng
NO Juan Manuel Henríquez-Jurado, Iván José Fuentes-Abolafio, Celia García-Conejo, Antonio Ignacio Cuesta-Vargas, Effectiveness of different exercise modalities in Heart Failure with preserved Ejection Fraction. A systematic review with network meta-analysis, Brazilian Journal of Physical Therapy, Volume 30, Issue 3, 2026, 101596, ISSN 1413-3555, https://doi.org/10.1016/j.bjpt.2026.101596.
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 5 may 2026