RT Journal Article
T1 The Use of β-Blockers and the Risk of Undergoing a Knee Arthroplasty. A Nested Case-Control Study.
A1 Tamimi-Mariño, Iskandar Ahmad
A1 García Meléndez, Gaspar
A1 Vieitez-Riestra, Ignacio
A1 Palacios-Penedo, Sergio
A1 Moriel-Garceso, Diego
A1 Sanchez, Alejandro
A1 Tamimi, Faleh
A1 Guerado-Parra, Enrique
A1 Dawid-Milner, Marc Stefan
A1 García-de-Quevedo-Puerta, David
A1 González-Quevedo, David
K1 Rodillas
K1 Operaciones quirúrgicas
K1 Cirugía - Complicaciones y secuelas
K1 Beta-bloqueantes
AB Background: The objective of this study was to analyze the likelihood of total knee arthroplasty (TKA) among patients with OA who were being treated with β-blockers.Methods: A nested case-control study was conducted with use of clinical records from our institutional database. We included patients who attended our outpatient clinic with a history of new-onset knee pain between 2010 and 2019. The case group included individuals who had undergone primary TKA between 2018 and 2019, whereas the control group included subjects who had not undergone TKA. Results: A total of 600 patients were included (300 in the case group and 300 in the control group). Compared with non-users, any use of β-blockers during the follow-up period was associated with a reduction in the likelihood of undergoing TKA (adjusted odds ratio [OR], 0.51; 95% confidence interval [CI], 0.34-0.77). The adjusted ORs for the use of selective β1-blockers and nonselective β1-blockers were 0.69 (95% CI, 0.36 to 1.31) and 0.42 (95% CI, 0.24 to 0.70), respectively. The adjusted ORs for any recent use, PDC of <0.25, PDC of ≥0.25 to <0.75, and PDC of ≥0.75 were 0.65 (95% CI, 0.51 to 0.99), 0.62 (95% CI, 0.21 to 1.85), 0.32 (95% CI, 0.09 to 1.22), and 0.55 (95% CI, 0.34 to 0.88), respectively. Regarding the cumulative effect of β-blockers, the adjusted ORs for the use for <1 year, ≥1 to <5 years, and ≥5 years were 0.41 (95% CI, 0.20 to 0.85), 0.52 (95% CI, 0.21 to 1.33), and 0.36 (95% CI, 0.22 to 0.60), respectively.Conclusions: The use of nonselective β-blockers was associated with a lower likelihood of undergoing TKA. Patients treated for prolonged periods were at a lower likelihood for undergoing TKA.
PB Wolters Kluwer Health
YR 2024
FD 2024-10-04
LK https://hdl.handle.net/10630/36005
UL https://hdl.handle.net/10630/36005
LA eng
NO Tamimi I, García-Meléndez G, Vieitez-Riestra I, Palacios-Penedo S, Garceso DM, Sanchez A, Tamimi F, Guerado E, Milner MSD, de Quevedo DG, Gonzalez-Quevedo D. The Use of β-Blockers and the Risk of Undergoing a Knee Arthroplasty: A Nested Case-Control Study. J Bone Joint Surg Am. 2023 Oct 4;105(19):1494-1501. doi: 10.2106/JBJS.22.01189. Epub 2023 Sep 5. PMID: 37669477.
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DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026