RT Journal Article
T1 Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial
A1 Domínguez-López, Inés
A1 Lamuela-Raventós, Rosa M.
A1 Razquin, Cristina
A1 Arancibia-Riveros, Camila
A1 Galkina, Polina
A1 Salas-Salvadó, Jordi
A1 Alonso-Gómez, Ángel M.
A1 Fitó, Montserrat
A1 Fiol, Miquel
A1 Lapetra, José
A1 Gómez-Gracia, Enrique
A1 Sorlí, José V.
A1 Ruiz-Canela, Miguel
A1 Castañer, Olga
A1 Liang, Liming
A1 Serra-Majem, Lluís
A1 Hu, Frank B.
A1 Ros, Emilio
A1 Martínez-González, Miguel Ángel
A1 Estruch, Ramón
K1 Marcadores bioquímicos
K1 Sistema cardiovascular - Enfermedades
AB Background and AimsModerate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations.However, wine consumption information through self-reports is prone to measurement errors inherent to subjective as-sessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker ofwine consumption, and the rate of a composite clinical CVD event.Methods A case-cohort nested study was designed within the PREDIMED trial with 1232 participants: 685 incident cases of CVD and arandom subcohort of 625 participants (including 78 overlapping cases). Wine consumption was registered using validated food frequency questionnaires. Liquid chromatography-tandem mass spectrometry was used to measure urinary tartaric acid at base-line and after one year of intervention. Weighted Cox regression models were used to estimate hazard ratios (HRs) of CVD.Results Tartaric acid was correlated with self-reported wine consumption at baseline [r = 0.46 (95% CI 0.41; 0.50)]. Five categories of post hoc urinary tartaric acid excretion were used for better representation of risk patterns. Concentrations of 3–12 and 12–35 μg/mL, which reflect ∼3–12 and 12–35 glasses/month of wine, were associated with lower CVD risk [HR 0.62 (95% CI 0.38; 1.00), P = .050 and HR 0.50 (95% CI 0.27; 0.95), P = .035, respectively]. Less significant associations between self-reported wine consumption and CVD risk were observed.
PB Oxford Academic
YR 2025
FD 2025-01-07
LK https://hdl.handle.net/10630/44708
UL https://hdl.handle.net/10630/44708
LA eng
NO Domínguez-López I, Lamuela-Raventós RM, Razquin C, Arancibia-Riveros C, Galkina P, Salas-Salvadó J, Alonso-Gómez ÁM, Fitó M, Fiol M, Lapetra J, Gómez-Gracia E, Sorlí JV, Ruiz-Canela M, Castañer O, Liang L, Serra-Majem L, Hu FB, Ros E, Martínez-González MÁ, Estruch R. Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial. Eur Heart J. 2025 Jan 7;46(2):161-172. doi: 10.1093/eurheartj/ehae804. PMID: 39689849; PMCID: PMC11704392.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026