RT Journal Article T1 Dietary Melanoidins from Biscuits and Bread Crust Alter the Structure and Short-Chain Fatty Acid Production of Human Gut Microbiota. A1 Rajakaruna, Sumudu A1 Pérez-Burillo, Sergio A1 Kramer, Denise Lynette A1 Rufián-Henares, José Ángel A1 Paliy, Oleg K1 Flora intestinal K1 Ácidos grasos K1 Antioxidantes K1 Melanoides AB Melanoidins are the products of the Maillard reaction between carbonyl and amino groupsof macromolecules and are readily formed in foods, especially during heat treatment. In this studywe utilized the three-stage Human Gut Simulator system to assess the effect of providing melanoidinsextracted from either biscuits or bread crust to the human gut microbiota. Addition of melanoidins tothe growth medium led to statistically significant alterations in the microbial community composition,and it increased short-chain fatty acid and antioxidant production by the microbiota. The magnitudeof these changes was much higher for cultures grown with biscuit melanoidins. Several lines ofevidence indicate that such differences between these melanoidin sources might be due to the presenceof lipid components in biscuit melanoidin structures. Because melanoidins are largely not degradedby human gastrointestinal enzymes, they provide an additional source of microbiota-accessiblenutrients to our gut microbes PB MDPI YR 2022 FD 2022-06-22 LK https://hdl.handle.net/10630/38621 UL https://hdl.handle.net/10630/38621 LA eng NO Rajakaruna S, Pérez-Burillo S, Kramer DL, Rufián-Henares JÁ, Paliy O. Dietary Melanoidins from Biscuits and Bread Crust Alter the Structure and Short-Chain Fatty Acid Production of Human Gut Microbiota. Microorganisms. 2022;10:1268. DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 20 ene 2026