RT Journal Article
T1 Fatigue in pediatric patients with inflammatory bowel disease: a multicenter study by the SEGHNP
A1 Martin-Masot, Rafael
A1 Velasco Rodríguez-Belvís, Marta
A1 Pujol Muncunil, Gemma
A1 Palomino, Laura
A1 Sánchez Sánchez, César
A1 Martín de Carpi, Javier
A1 Navas-López, Víctor Manuel
K1 Aparato digetivo-Enfermedades-Niños
K1 Calidad de vida
K1 Fatiga (Fisiología)
AB Background: Fatigue is a common and disabling symptom in pediatric inflammatory bowel disease (IBD), often persistingeven during clinical remission and reflecting a multifactorial origin. Despite its significant impact on patients' lives, it remainsunder-recognized. The IMPACT-III and IMPACT-III-P questionnaires facilitate fatigue assessment within a biopsychosocialframework of health-related quality of life (HRQOL).Methods: In this multicenter study supported by the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition(SEGHNP), 382 patients aged 10-17 years and their caregivers from 37 hospitals completed the IMPACT-III and IMPACT-III-Pquestionnaires between February 2021 and June 2023. Fatigue-related items were analyzed, and predictive models were de-veloped using univariate and multivariate logistic regression.Results: A total of 370 patient questionnaires were included in the analysis. The median age at diagnosis was 11.3 years (inter-quartile range [IQR] 8.7-13.3), and at assessment, 14.4 years (IQR 12.4–16.1). Males represented 56% of the cohort, and 61.1%had Crohn’s disease. Treatments included immunosuppressants (44.6%), 5-ASA (33.7%), biologics (30.8%), corticosteroids(6%), and other therapies (27.8%). Fatigue was reported by 81.1% of patients, including 77.5% of those in clinical remission.Severe fatigue was significantly associated with female sex, older age, active disease, and dietary treatment. Conversely,absence of fatigue was independently associated with male sex, earlier pubertal stage, and not receiving biologics. Notablediscrepancies were observed between patient and caregiver perceptions of energy levels. Fatigue correlated with significant-ly lower HRQOL scores across all IMPACT-III domains. In Crohn’s disease, the strongest impacts were observed in the social andsystemic domains, whereas in ulcerative colitis, emotional and physical domains were more affected. Patients without severefatigue consistently scored higher in all domains.Conclusion: Fatigue is a highly prevalent and multifactorial symptom in pediatric IBD, with a marked negative impact on qual-ity of life, even in clinical remission. The IMPACT-III and IMPACT-III-P questionnaires are valuable tools for its assessment andhighlight the need for routine, systematic evaluation of fatigue to guide holistic and individualized management strategies.
PB Oxford University Press
YR 2026
FD 2026-02
LK https://hdl.handle.net/10630/46131
UL https://hdl.handle.net/10630/46131
LA eng
NO Rafael Martin-Masot, Marta Velasco Rodríguez-Belvís, Gemma Pujol Muncunill, Laura Palomino, César Sánchez Sánchez, Javier Martín de Carpi, Víctor Manuel Navas-López, Inflammatory Bowel Disease Working Group of SEGHNP (Spanish Pediatric Gastroenterology, Hepatology and Nutrition Society), Fatigue in pediatric patients with inflammatory bowel disease: a multicenter study by the SEGHNP, Crohn's & Colitis 360, Volume 8, Issue 1, January 2026, otag005, https://doi.org/10.1093/crocol/otag005
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026