RT Journal Article
T1 Dietary and Smoking Acrylamide and Prostate Cancer Risk: CAPLIFE Study
A1 Lozano-Lorca, Macarena
A1 Muñoz-Bravo, Carlos
A1 Barrios-Rodríguez, Rocío
A1 Castillo-Hermoso, María Ángeles
A1 Kouiti, Malak
A1 González-Palacios Torres, Carla
A1 Jiménez-Moleón, José Juan
A1 Olmedo-Requena, Rocío
K1 Dieta
K1 Tabaquismo
AB Acrylamide is a probable carcinogen. Its main sources are the diet and tobacco. Theassociation between acrylamide intake from the diet and tobacco and prostate cancer (PCa) hasnot been previously evaluated. We aimed to evaluate the relationship between dietary acrylamideintake and exposure to acrylamide through cigarettes and PCa risk. A population-based case–control(CAPLIFE) study was conducted, including 428 incident PCa cases and 393 controls. Smoking anddietary information, with a validated food frequency questionnaire, was collected. We calculatedthe amount of acrylamide from both sources, and tertiles (Ts) were created. Multivariable logisticregression and restricted cubic spline models were applied to assess the association between exposureto acrylamide and PCa risk. The median was similar for acrylamide in both dietary and smokingacrylamide among PCa cases and controls. No association was observed between dietary acrylamideintake and overall PCa risk (adjusted ORT3vsT1 = 0.90 (95% CI 0.59, 1.37)). A risk trend was observedfor acrylamide exposure from cigarette smoking (p-trend = 0.032), with the highest odds in thosesubjects with the high exposure to acrylamide through cigarettes (adjusted ORT3vsT1 = 1.67 (95% CI0.92, 3.04)). The restricted cubic splines suggested a linear relationship. In conclusion, acrylamidefrom smoking could be positively associated with PCa risk, but no association was observed fordietary acrylamide.
PB MDPI
YR 2024
FD 2024
LK https://hdl.handle.net/10630/33495
UL https://hdl.handle.net/10630/33495
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026