RT Journal Article
T1 Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
A1 Tinahones-Madueño, Francisco José
A1 Queipo Ortuño, Maria Isabel
A1 Clemente-Postigo, María Mercedes
A1 Fernandez-García, Diego
A1 Mingrone, Geltrude
A1 Cardona-Díaz, Fernando
K1 Obesidad - Cirugía
K1 Resistencia a la insulina
AB Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. Evidence has shown that patients with morbid obesity have postprandial hypertriglyceridemia (HTG) and that this type of HTG is related to the degree of insulin resistance. Also, bariatric surgery produces a dramatic reduction in triglyceride levels. However, it is unknown whether patients with postprandial HTG have a different clinical evolution after bariatric surgery. The setting of our study was a university hospital. We studied 57 morbidly obese patients who had mild or severe postprandial HTG after fat overload (<30 mg/dL or >90 mg/dL increase in triglycerides, respectively). All the patients underwent bariatric surgery. After surgery, the anthropometric and biochemical variables and the Homeostasis Model Assessment of Insulin Resistance were measured for 1 year at 0, 15, 30, 45, 90, 180, and 365 days after surgery. The patients with more severe postprandial HTG had a greater percentage of change in the Homeostasis Model Assessment of Insulin Resistance at 30, 90, and 180 days after surgery than the patients with less severe postprandial HTG. Multiple regression analysis showed that the postprandial triglyceride levels predict the variation in the Homeostasis Model Assessment of Insulin Resistance index, more so than did traditional variables, such as anthropometric, inflammatory, or hormonal data. The postprandial HTG level might be the best predictor of improved insulin resistance in morbidly obese patients after bariatric surgery.
PB Elsevier
YR 2013
FD 2013
LK https://hdl.handle.net/10630/35693
UL https://hdl.handle.net/10630/35693
LA eng
NO Política de acceso abierto tomada de: https://openpolicyfinder.jisc.ac.uk/id/publication/16756
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026