RT Journal Article
T1 Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes
A1 Reyes Palomares, Arturo
A1 Castillo-Domínguez, Adrián
A1 Ruiz-Galdón, Maximiliano
A1 Rodriguez-Wallberg, Kenny
A1 Reyes-Engel, Armando
K1 Fecundación humana in vitro
AB PurposeSingle-nucleotide polymorphisms (SNPs) in the p53 pathways have shown to play a role in endometrial receptivity and implantation in infertile women undergoing in vitro fertilization (IVF). The present study aimed to assess the influence of these gene variants over pregnancy success through a receptivity model in recipients of egg donation treatments, when factors such as age and quality of the oocytes are standardized.MethodsA nested case–control study was performed on 234 female patients undergoing their first fresh IVF treatment as recipients of donor oocytes. Genotyping of TP53 Arg72Pro (rs1042522), LIF (rs929271), MDM4 (rs1563828), and USP7 (rs1529916) SNPs in the recipients allowed comparison of allele and genotype frequencies and their association with the IVF treatment outcome.ResultsGrouped by genotypes, patients showed differences in IVF outcomes after the embryo transfer. Arg72Pro (rs1042522) gene variant was associated to changes in implantation and clinical pregnancy rates. The polymorphisms USP7 (rs1529916) and MDM4 (rs1563828) were associated to differential ongoing pregnancy rates and variable miscarriage events, respectively.ConclusionsThis study highlights the association between gene polymorphisms related to P53 function and their influence over IVF reproductive outcomes. Arg72Pro variant may influence early events, as lower implantation rates were found in homozygous for Pro72 allele. By contrast, MDM4 (rs1563828) and USP7 (rs1529916) gene variants were associated with the later maintenance of pregnancy.
PB Springer Nature
YR 2021
FD 2021-10-07
LK https://hdl.handle.net/10630/44673
UL https://hdl.handle.net/10630/44673
LA eng
NO Palomares, A.R., Castillo-Domínguez, A.A., Ruiz-Galdón, M. et al. Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes. J Assist Reprod Genet 38, 3267–3275 (2021). https://doi.org/10.1007/s10815-021-02324-9
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026