RT Journal Article
T1 Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition
A1 Beltran-Casanueva, Rasiel
A1 Hernández-García, Aracelis
A1 de Amo García, Paula
A1 Blanco-Reina, Encarnación
A1 Serrano-Castro, Pedro
A1 García-Casares, Natalia
A1 Fuxe, Kjell
A1 Borroto Escuela, Dasiel Óscar
A1 Narváez, Manuel
K1 Neuropéptidos
AB Introduction: This study may unveil novel insights into the interactions between neuropeptide Y receptor 1 (NPY1R) and galanin receptor 2 (GALR2), in the dentate gyrus of the dorsal hippocampus, shedding light on their role in neurogenesis and cognitive functions. Existing literature highlights the potential of these interactions in enhancing learning and memory, yet detailed mechanisms remain underexplored.Methods: Utilizing intracerebroventricular injections of GALR2 and NPY1R agonists in Sprague-Dawley male rats, we examined neurogenesis via markers PCNA and DCX, and memory consolidation through the object-in-place task over a three-week period.Results: Significant increases in NPY1R-GALR2 co-localization and neuroblast proliferation were observed, alongside enhanced memory consolidation. These findings suggest a synergistic effect of NPY1R and GALR2 activation on cognitive functions.Discussion: Our findings may foster the development of novel heterobivalent or multitargeting drugs, affecting NPY1R-GALR2 interaction, and suggest a future pharmacogical strategy for improving learning and memory found in many brain diseases. Further research is encouraged to explore these mechanisms in pathological models.
YR 2024
FD 2024-02-14
LK https://hdl.handle.net/10630/33406
UL https://hdl.handle.net/10630/33406
LA eng
NO Beltran-Casanueva R, Hernández-García A, de Amo García P, Blanco-Reina E, Serrano-Castro P, García-Casares N, Fuxe K, Borroto-Escuela DO and Narváez M (2024) Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition. Front. Cell. Neurosci. 18:1323986. doi: 10.3389/fncel.2024.1323986
NO The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the UMA18-FEDERJA-100 and ProyExcel_00613, Junta de Andalucía, Spain, to MN. Beca de Iniciación a la investigación de la Universidad de Málaga to PA. Funding for open access charge: Universidad de Málaga/CBUA. Additional funding support came from Cátedra Imbrain: Neurociencia Integrada y Bionestar to MN. This work also received support from Stiftelsen Olle Engkvist Byggmästare in 2018 and 2021, as well as from the Swedish Medical Research Council (GrantNo. 62X-00715-50-3) awarded to KF and DB-E. Additionally, funding was provided by Hjärnfonden (Grants F02018-0286 and F02019-0296), Karolinska Institutet Forskningsstiftelser 2022, EMERGIA 2020-39318 (Plan Andaluz de Investigación, Desarrollo e Innovación 2020), and CONSOLIDACION INVESTIGADORA(CNS2022-136008, Programa Estatal para Desarrollar, Atraer y Retener Talento, del Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023) awarded to DB-E. DB-E is affiliated with the Academia de Biólogos Cubanos and the Observatorio Cubano de Neurociencias (Yaguajay, Cuba).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026