RT Journal Article
T1 Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker
A1 Molina, Noemí
A1 Nájera-Albendín, Francisco
A1 Guadix-Domínguez, Juan Antonio
A1 perez-pomarez, Jose M
A1 Vida-Pol, Yolanda
A1 Perez-Inestrosa, Ezequiel
K1 Marcadores bioquímicos
AB Herein, we present an easy and efficient synthesis of amino terminal dendrons, combining protection/deprotection reactions with copper-catalyzed azide alkyne cycloaddition in a convergent way. This new approach affords dendrons in gram scale with excellent yields and easy purification. By choosing the appropriate azido-functionalized core, these dendrons lead to a more efficient and controlled convergent synthesis of dendrimers with different sizes and shapes and multivalence. The amino terminal dendrimers were analyzed by diffusion-ordered spectroscopy experiments. The observed dendrimer size is in excellent correlation with the expected size and shape by molecular dynamic simulations. The construction of these kinds of nanostructures, in a simple and efficient way, opens new opportunities for biomedical applications. Moreover, by choosing the appropriate core, these versatile macromolecules become an excellent fluorescent biomarker.
PB ACS Publications
YR 2019
FD 2019
LK https://hdl.handle.net/10630/36105
UL https://hdl.handle.net/10630/36105
LA eng
NO Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369
NO Spanish Ministerio de Economı́a, Industria y Competitividad Instituto de Salud Carlos IIIConcsejerı́a de Salud, Junta de Andalucı́aFEDER founds
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026