RT Journal Article
T1 Cannabidiol effects in stem cells: A systematic review.
A1 Mesas, Cristina
A1 Moreno, Javier
A1 Doello, Kevin
A1 Peña, Mercedes
A1 López-Romero, Juan Manuel
A1 Prados, José
A1 Melguizo, Consolación
K1 Células madre
K1 Células cancerosas
K1 Cannabinoides - Receptores
AB Stem cells play a critical role in human tissue regeneration and repair. In addi-tion, cancer stem cells (CSCs), subpopulations of cancer cells sharing similarcharacteristics as normal stem cells, are responsible for tumor metastasis andresistance to chemo- and radiotherapy and to tumor relapse. Interestingly, allstem cells have cannabinoid receptors, such as cannabidiol (CBD), that per-form biological functions. The aim of this systematic review was to analyze theeffect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articlesanalyzed, 38 were selected according to the inclusion and exclusion criteria. Atotal of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBDdifferentiation effect and 56% on its protective activity. On the other hand,11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%),lung cancer (27%), and breast cancer (only one article). Our results showedthat CBD exerted a differentiating and protective effect on SCCs. In addition,this molecule demonstrated an antiproliferative effect on some CSCs, althoughmost of the analyses were performed in vitro. Therefore, although in vivo stud-ies should be necessary to justify its clinical use, CBD and its receptors couldbe a specific target to act on both SSCs and CSCs.
PB Wiley
YR 2024
FD 2024-12-27
LK https://hdl.handle.net/10630/40465
UL https://hdl.handle.net/10630/40465
LA eng
NO Mesas C, Moreno J,Doello K, Peña M, L opez-Romero JM, Prados J,et al. Cannabidiol effects in stem cells: Asystematic review. BioFactors. 2025;51(1):e2148.https://doi.org/10.1002/biof.2148MESAS ET AL . 23 of 23
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026