RT Journal Article
T1 HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)
A1 Fernández Fernández, Óscar
A1 Rodríguez-Antigüedad, Alfredo
A1 Pinto-Medel, María Jesús
A1 Mendibe, Mari Mar
A1 Acosta, Nestor
A1 Oliver-Martos, Begoña
A1 Guerrero, Miguel
A1 Papais-Alvarenga, Marcos
A1 Fernández Sánchez, Victoria Eugenia
A1 Leyva-Fernández, Laura
K1 Esclerosis múltiple
AB Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major histocompatibilitycomplex, particularly with the HLA DRB1*1501-DQA1*0102-DQB1*0602 haplotype in Caucasians. Toinvestigate the association of DRB1, DQA1 and DQB1 alleles and haplotypes with MS in Biscay, Basque Country, northern Spain, we examined 197 patients and 200 regionally matched controls. High resolution HLA class II typing was performed by polymerase chain reaction followed by sequence-specific oligonucleotide probe hybridization. Several alleles were overrepresented in MS patients comparedwith those of controls: DRB1*0402, DRB1*1303, DRB1*1501, DQA1*0102, DQB1*0301, and DQB1*0602.DQB1*0602 was the only potentially predisposing allele for MS that withstood Bonferroni correction and maintained the association in a logistic regression model. On the other hand, several alleles showed lower frequencies in the MS group: DRB1*0101, DQA1*0101, DQB1*0303, and DQB1*0501,but only DRB1*0101 and DQB1*0303 maintained a negative association with the disease in the regression analysis.Three haplotypes were identified as potentially predisposing for MS in our population: DRB1*1501-DQA1*0102-DQB1*0602, DRB1*0402-DQA1*0301-DQB1*0302, and HLA-DRB1*013-DQA1*05-DQB1*0301. Additionally, three haplotypes associated with a lower risk for MS were identified, exhibiting DRB1*0101-DQA1*0101-DQB1*0501 the strongest negative association with MS [12% in controls vs. 3.8% in MS, Pc = 0.00047, OR = 0.290 (95%CI = 0.160–0.528)], and suggesting, therefore, a putative protective role for this haplotype in the population under study.
PB Springer
YR 2009
FD 2009
LK https://hdl.handle.net/10630/32832
UL https://hdl.handle.net/10630/32832
LA eng
NO Fernández O, R-Antigüedad A, Pinto-Medel MJ, Mendibe MM, Acosta N, Oliver B, Guerrero M, Papais-Alvarenga M, Fernández-Sánchez V, Leyva L. HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). J Neurol. 2009 Dec;256(12):1977-88
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026