RT Conference Proceedings
T1 Neuropathological events in an animal model resembling human fetal post-hemorrhagic hydrocephalus
A1 Ojeda-Pérez, Betsaida
A1 Páez-González, Patricia
A1 Jiménez-Lara, Antonio Jesús
K1 Espina bífida -- Congresos
K1 Hidrocefalia -- Congresos
AB Introduction:In premature newborns, intraventricular hemorrhages (IVH) probably trigger the disruption of the neurogenic ventricular zone. Most of the cases with severe IVH develop post-hemorrhagic hydrocephalus (PHH). A mouse model with IVH has been developed to research into the common neuropathological events present in PHH and into possible therapies.Methods:In two-day-old mice, the blood serum from littermates was injected into the ganglionic eminence of one hemisphere or both hemispheres. Fourteen days later, a histopathological analysis was carried out. In the case of injection in one hemisphere, the effects were compared with the contralateral non-injected hemisphere.Results:Mice with IVH developed the following neuropathological effects. The ependyma was found denuded and replaced by reactive astrocytes. A reaction of astrocytes over-expressing aquaporin-4 and of NG2 cells was also found developed in the white matter. Alterations in the neurogenesis were also common in the ventricular zone and in the white matter.Conclusions:The animal model of IVH developed shows similar neuropathological events to other forms of congenital hydrocephalus and can be used to research into therapies for PHH.
YR 2019
FD 2019-07-03
LK https://hdl.handle.net/10630/17935
UL https://hdl.handle.net/10630/17935
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PI15/0619 (ISCIII/FEDER) to AJJ.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026