RT Journal Article
T1 Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
A1 El-Bekay, Rajaa
A1 Coín-Aragüez, Leticia I.
A1 Fernandez-García, Diego
A1 Oliva Olivera, Wilfredo
A1 Bernal-López, María Rosa
A1 Clemente-Postigo, María Mercedes
A1 Delgado-Lista, Javier
A1 Díaz-Ruiz, Alberto
A1 Guzmán-Ruiz, Rocio
A1 Vázquez-Martínez, Rafael
A1 Lhamyani, Said
A1 Roca-Rodríguez, María del Mar
A1 Fernández-Veledo, Sonia
A1 Vendrell, Joan
A1 Malagón, Maria M.
A1 Tinahones-Madueño, Francisco José
K1 Péptidos
K1 Obesidad - Aspectos moleculares
K1 Tejido adiposo
AB Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss inobese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present in adipocytesand the stromal vascular fraction of human adipose tissue (AT), is up-regulated in AT of insulin-resistant morbidly obese subjectscompared with healthy lean subjects. The aim of this study was to explore the effects of in vitro and in vivo administration of GLP-1and its analogues on AT and adipocyte functions from T2D morbidly obese subjects.
PB British Pharmacological Society
YR 2016
FD 2016-03-18
LK https://hdl.handle.net/10630/34724
UL https://hdl.handle.net/10630/34724
LA eng
NO https://v2.sherpa.ac.uk/id/publication/6832
NO This work was supported by grants from the Spanish Ministry of Health (FIS) (PI12/02355, PS09/00997 and PI13/02628), the Consejería de Innovación and co-funded by Fondo Europeo de Desarrollo Regional–FEDER (CTS04369, CTS-03039, PI11-CTS-8181 and PI11-CTS-7895) and the Ministerio de Economía y Competitividad and co-funded by Fondo Europeo de Desarrollo Regional–FEDER (BFU2010–17116). Rajaa El Bekay is recipient of a post-doctoral grant ‘Miguel Servet II’ (CPII13/00041) from the Spanish Ministry of Health. CIBERobn is an initiative of ISCIII (Instituto de Salud Carlos III), Spain. M.C.P. was recipient of a FPU grant from the Ministry of Education (Spain) (AP2009–4537).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026