RT Journal Article
T1 SALON ontology for the formal description of sequence alignments.
A1 Benítez-Hidalgo, Antonio
A1 Aldana-Montes, José Francisco
A1 Navas-Delgado, Ismael
A1 Roldán-García, María del Mar
K1 Ontologías (Recuperación de la información)
K1 Proceso electrónico de datos
K1 Web semántica
K1 Datos enlazados
AB BackgroundInformation provided by high-throughput sequencing platforms allows the collection of content-rich data about biological sequences and their context. Sequence alignment is a bioinformatics approach to identifying regions of similarity in DNA, RNA, or protein sequences. However, there is no consensus about the specific common terminology and representation for sequence alignments. Thus, automatically linking the wide existing knowledge about the sequences with the alignments is challenging.ResultsThe Sequence Alignment Ontology (SALON) defines a helpful vocabulary for representing and semantically annotating pairwise and multiple sequence alignments. SALON is an OWL 2 ontology that supports automated reasoning for alignments validation and retrieving complementary information from public databases under the Open Linked Data approach. This will reduce the effort needed by scientists to interpret the sequence alignment results.ConclusionsSALON defines a full range of controlled terminology in the domain of sequence alignments. It can be used as a mediated schema to integrate data from different sources and validate acquired knowledge.
PB BMC
YR 2023
FD 2023-02-27
LK https://hdl.handle.net/10630/30665
UL https://hdl.handle.net/10630/30665
LA eng
NO Benítez-Hidalgo, A., Aldana-Montes, J.F., Navas-Delgado, I. et al. SALON ontology for the formal description of sequence alignments. BMC Bioinformatics 24, 69 (2023). https://doi.org/10.1186/s12859-023-05190-7
NO This work has been partially funded by the Spanish Ministry of Science and Innovation via Grant PID2020-112540RB-C41 (AEI/FEDER, UE) and Andalusian PAIDI program with grant P18-RT-2799. Antonio Benítez-Hidalgo is supported by Grant PRE2018-084280 (Spanish Ministry of Science, Innovation and Universities).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026