RT Journal Article T1 Mediterranean diet and risk of breast cancer: An umbrella review A1 González-Palacios Torres, Carla A1 Barrios-Rodríguez, Rocío A1 Muñoz-Bravo, Carlos A1 Toledo, Estefanía A1 Dierssen, Trinidad A1 Jiménez-Moleón, José Juan K1 Mamas-Cáncer-Prevención K1 Hábitos alimenticios K1 Dieta K1 Nutrición K1 Dieta en enfermedades AB BackgroundThe Mediterranean Diet (MedDiet) is a healthy dietary pattern which has been related to a lower risk of certain chronic diseases, such as some cancers. However, its role in breast cancer development remains unclear. This umbrella review aims to summarize the highest available evidence on MedDiet and breast cancer risk.MethodsPubmed, Web of Science, and Scopus electronic platforms were searched for relevant systematic reviews and meta-analyses. The selection criteria included systematic reviews with or without meta-analysis including women aged 18 years or older which evaluated the adherence to a MedDiet as the exposure and incidence of breast cancer as the outcome variable. Overlapping and quality of the reviews using AMSTAR-2 tool were independently assessed by two authors.ResultsFive systematic reviews and six systematic reviews with meta-analysis were included. Overall, 4 systematic reviews – two with and two without meta-analysis – were rated as of high quality. An inverse association was found in 5 of the 9 reviews which evaluated the role of MedDiet on the risk of total breast cancer. The meta-analyses showed moderate-high heterogeneity. The risk reduction seemed to be more consistent among postmenopausal women. No association was found for MedDiet among premenopausal women.ConclusionsThe results of this umbrella review suggest that adherence to a MedDiet pattern had a protective effect on the risk of breast cancer, especially for postmenopausal breast cancer. The stratification of breast cancer cases and conducting high-quality reviews are aspects needed to overcome the current results’ heterogeneity and to improve knowledge in this field. PB Elsevier YR 2023 FD 2023 LK https://hdl.handle.net/10630/26287 UL https://hdl.handle.net/10630/26287 LA eng NO González-Palacios Torres C, Barrios-Rodríguez R, Muñoz-Bravo C, Toledo E, Dierssen T, Jiménez-Moleón JJ. Mediterranean diet and risk of breast cancer: An umbrella review. Clin Nutr. 2023 Apr;42(4):600-608. doi: 10.1016/j.clnu.2023.02.012. Epub 2023 Feb 23. PMID: 36893621.https://doi.org/10.1016/j.clnu.2023.02.012. NO Funding for open access charge: Universidad de Málaga / CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 20 ene 2026