RT Journal Article
T1 Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance
A1 García Aranda, Marilina
A1 Téllez-Santana, Teresa
A1 McKenna, Lauraine
A1 Redondo-Bautista, Maximino
K1 Cáncer
AB Nowadays, the identification of new therapeutic targets that allow for the development of treatments, which as monotherapy, or in combination with other existing treatments can contribute to improve response rates, prognosis and survival of oncologic patients, is a priority to optimize healthcare within sustainable health systems. Recent studies have demonstrated the role of Substance P (SP) and its preferred receptor, Neurokinin 1 Receptor (NK-1R), in human cancer and the potential antitumor activity of NK-1R antagonists as an anticancer treatment. In this review, we outline the relevant studies published to date regarding the SP/NK-1R complex as a key player in human cancer and also evaluate if the repurposing of already marketed NK-1R antagonists may be useful in the development of new treatment strategies to overcome cancer resistance
PB IOAP-MPDI
YR 2022
FD 2022-04-30
LK https://hdl.handle.net/10630/24384
UL https://hdl.handle.net/10630/24384
LA eng
NO García-Aranda M, Téllez T, McKenna L, Redondo M. Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance. Cancers. 2022; 14(9):2255. https://doi.org/10.3390/cancers14092255
NO The researcher Marilina García-Aranda is the benefactor of a postdoctoral contract financedby the European Social Fund—Operational Program of Andalusia 2014–2020 for the “Incorporationof Research Personnel with a PhD degree in the field of Health Sciences and Technologies in R&Dand Innovation Centers of the Public Health System of Andalusia” (RH-0055-2020). This workwas partially supported by grant from the University of Malaga—Consejería de TransformaciónEconómica, Industria, Conocimiento y Universidades—Junta de Andalucia (UMA20-FEDERJA-161).Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026