RT Journal Article
T1 Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex
A1 García-Marchena, Nuria
A1 Marcos, Alberto
A1 Flores-López, María
A1 Moreno-Fernández, Mario
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Torres-Galván, Sandra
A1 Araos Gómez, Pedro Fernando
A1 Serrano, Antonia
A1 Muga, Roberto
A1 Ruiz-Ruiz, Juan Jesús
A1 Rodriguez-de-Fonseca, Fernando
A1 Ambrosio, Emilio
A1 Pavón-Morón, Francisco Javier
K1 Drogas -- Aspectos psíquicos
AB (1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. (2) Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity (3) Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. (4) Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.
PB MPDI
YR 2022
FD 2022-05-14
LK https://hdl.handle.net/10630/24247
UL https://hdl.handle.net/10630/24247
LA eng
NO García-Marchena N, Marcos A, Flores-López M, Moreno-Fernández M, Requena-Ocaña N, Porras-Perales O, Torres-Galván S, Araos P, Serrano A, Muga R, Ruiz-Ruiz JJ, Rodríguez de Fonseca F, Ambrosio E, Pavón-Morón FJ. Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex. Biomedicines. 2022; 10(5):1137. https://doi.org/10.3390/biomedicines10051137
NO This research was supported by the following programs and projects: JUST-DRUGS-AGHOME Action Grant (JUST-2017-AG-DRUG-806996-JUSTSO) funded by the European Commission; Subprograma Redes Temáticas RETICS (Red de Trastornos Adictivos RD16/0017/0001 andRD16/0017/0022) funded by Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad and the European Regional Development Funds/European Social Fund (ERDF/ESF);Proyectos de Investigación en Salud (PI19/00886, PI19/01577 and PI20/01399) funded by ISCIII andERDF/ESF; Proyectos de I+D+I (PID2019-111594RB-I00) funded by Agencia Estatal de Investigación,Ministerio de Ciencia e Innovación; Proyectos de Investigación en Drogodependencias (2016I0732017I043, 2018I033, 2018I044 and 2021I043) funded by Delegación del Gobierno para el Plan Nacionalsobre Drogas, Ministerio de Sanidad and ERDF/ESF; Proyectos de Investigación en Salud (PI-0140-2018) funded by Consejería de Salud y Familias, Junta de Andalucía and ERDF/ES; Proyectos I+D+Ien el marco del Programa Operativo FEDER Andalucía 2014–2020 (UMA18-FEDERJA-059) funded byConsejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía and ERDF/ESF;and UNED (Plan de Promoción de la Investigación). NGM holds a “Sara Borrell” research contract(CD19/00019) funded by ISCIII and ERDF/ESF. FJP and AS hold a “Miguel Servet II” researchcontract (CPII19/00022 and CPII19/00031, respectively) funded by ISCIII and ERDF/ESFPartial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026