RT Journal Article
T1 Magnetic Nanoparticles with On-Site Azide and Alkyne Functionalized Polymer Coating in a Single Step through a Solvothermal Process
A1 Mora-Cabello, Romualdo
A1 Fuentes-Ríos, David
A1 Gago, Lidia
A1 Cabeza, Laura
A1 Moscoso, Ana
A1 Melguizo, Consolación
A1 Prados, José
A1 Sarabia-García, Francisco Ramón
A1 López-Romero, Juan Manuel
K1 Nanopartículas
K1 Polímeros
K1 Oxidos de hierro
AB Magnetic Fe3O4 nanoparticles (MNPs) are becoming more im-portant every day. We prepared MNPs in a simple one-step reaction by following the solvothermalmethod, assisted by azide and alkyne functionalized polyethylene glycol (PEG400) polymers, aswell as by PEG6000 and the polyol β-cyclodextrin (βCD), which played a crucial role as electrostaticstabilizers, providing polymeric/polyol coatings around the magnetic cores. Methods: The composi-tion, morphology, and magnetic properties of the nanospheres were analyzed using TransmissionElectron and Atomic Force Microscopies (TEM, AFM), Nuclear Magnetic Resonance (NMR), X-rayDiffraction Diffractometry (XRD), Fourier-Transform Infrared Spectroscopy (FT-IR), Matrix-AssistedLaser Desorption/Ionization (MALDI) and Vibrating Sample Magnetometry (VSM). Results: Theobtained nanoparticles (@Fe3O4-PEGs and @Fe3O4-βCD) showed diameters between 90 and 250 nm,depending on the polymer used and the Fe3O4·6H2O precursor concentration, typically, 0.13 M at200 ◦C and 24 h of reaction. MNPs exhibited superparamagnetism with high saturation massmagnetization at room temperature, reaching values of 59.9 emu/g (@Fe3O4-PEG6000), and no ferro-magnetism. Likewise, they showed temperature elevation after applying an alternating magneticfield (AMF), obtaining Specific Absorption Rate (SAR) values of up to 51.87 ±2.23 W/g for @Fe3O4-PEG6000. Additionally, the formed systems are susceptible to click chemistry, as was demonstratedin the case of the cannabidiol-propargyl derivative (CBD-Pro), which was synthesized and covalentlyattached to the azide functionalized surface of @Fe3O4-PEG400-N3. Prepared MNPs are highlydispersible in water, PBS, and citrate buffer, remaining in suspension for over 2 weeks, and non-toxicin the T84 human colon cancer cell line, Conclusions: indicating that they are ideal candidates forbiomedical applications.
PB MDPI
YR 2024
FD 2024
LK https://hdl.handle.net/10630/40460
UL https://hdl.handle.net/10630/40460
LA eng
NO Mora-Cabello, R.; Fuentes-Ríos, D.; Gago, L.; Cabeza, L.; Moscoso, A.; Melguizo, C.; Prados, J.; Sarabia, F.; López-Romero, J.M. Magnetic Nanoparticles with On-Site Azide and Alkyne Functionalized Polymer Coating in a Single Step through a Solvothermal Process. Pharmaceutics 2024, 16, 1226. https://doi.org/10.3390/pharmaceutics16091226
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026