RT Journal Article
T1 A comparison of the effect of convection against diffusion in hemodynamics and cytokines clearance in an experimental model of septic shock
A1 Herrera-Gutiérrez, Manuel Enrique
A1 Seller Pérez, Gemma Luisa
A1 Arias Verdú, Dolores
A1 Granados, Maria M.
A1 Domínguez, Juan M.
A1 Navarrete, Rocío
A1 Morgaz, Juan
A1 Gómez Villamandos, Rafael
K1 Citoquinas
K1 Enfermedades - Modelos animales
K1 Hemodinámica
AB BACKGROUND: Our aim was to define the efficacy of hemofiltration (convection) and hemodialysis (diffusion) in cytokine clearance and hemodynamicimprovement in an experimental model of septic shock.METHODS: Shock was induced in 15 beagle dogs (weight 10Y15 kg) by infusion of 1 mg/kg of ultrapure Escherichia coli lipopolysaccharidediluted in 20 mL saline for 10 minutes. Five animals were followed without interventions (controls), five animals were treated withconvection (100 mL kgj1 hj1) for 6 hours, and five animals were treated with diffusion (100 mL kgj1 hj) for 6 hours.RESULTS: All subjects in the control group died during the study, whereas all treated subjects survived. Mean arterial pressure, cardiac output,systolic variability volume, systemic vascular resistances, dPMax, and pulmonary compliance improved in treated subjects. However,the differences in mean arterial pressure and cardiac output were significant only in the convection group and not in the diffusiontreatedgroup.Tumor necrosis factor > rose equally in all groups and decreased only in treated subjects. Interleukin 6 rose in the three groups butdecreased only in the convection group and remained unchanged in the control and diffusion groups.CONCLUSION: Convection and diffusion improved survival and hemodynamic parameters in a septic shock model. Improvement was more pronouncedwith convection, a difference that may be explained by convective clearance of cytokines.
PB Wolters Kluwer
YR 2012
FD 2012-04-10
LK https://hdl.handle.net/10630/41164
UL https://hdl.handle.net/10630/41164
LA eng
NO Herrera-Gutiérrez ME, Seller-Pérez G, Arias-Verdú D, Granados MM, Dominguez JM, Navarrete R, Morgaz J, Gómez-Villamandos R. A comparison of the effect of convection against diffusion in hemodynamics and cytokines clearance in an experimental model of septic shock. J Trauma Acute Care Surg. 2012 Oct;73(4):855-60. doi: 10.1097/TA.0b013e31825eea8a. PMID: 22922966. Copy  Download .nbib For
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