RT Journal Article
T1 Absence of LPA1 signaling results in defective cortical development
A1 Estivill-Torrús, Guillermo
A1 Llebrez Zayas, Pedro
A1 Matas-Rico, Elisa
A1 Rodriguez-de-Fonseca, Fernando
A1 Chun, Jerold
A1 Santín-Núñez, Luis Javier
A1 Pedraza-Benítez, María del Carmen
A1 De-Diego-Barbado, Isabel
A1 Del Arco-Herrera, Ignacio
A1 Fernández-Llebrez, Pedro
K1 Cerebro - Evolución
AB Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing brain, the former enriched in the neurogenic ventricular zone (VZ), suggesting a normal role in neurogenesis. Despite numerous studies reporting the effects of exogenous LPA using in vitro neural models, the first LPA(1) loss-of-function mutants reported did not show gross cerebral cortical defects in the 50% that survived perinatal demise. Here, we report a role for LPA(1) in cortical neural precursors resulting from analysis of a variant of a previously characterized LPA(1)-null mutant that arose spontaneously during colony expansion. These LPA(1)-null mice, termed maLPA(1), exhibit almost complete perinatal viability and show a reduced VZ, altered neuronal markers, and increased cortical cell death that results in a loss of cortical layer cellularity in adults. These data support LPA(1) function in normal cortical development and suggest that the presence of genetic modifiers of LPA(1) influences cerebral cortical development.
PB Oxford academy
YR 2008
FD 2008-04
LK https://hdl.handle.net/10630/34538
UL https://hdl.handle.net/10630/34538
LA eng
NO Guillermo Estivill-Torrús, Pedro Llebrez-Zayas, Elisa Matas-Rico, Luis Santín, Carmen Pedraza, Isabel De Diego, Ignacio Del Arco, Pedro Fernández-Llebrez, Jerold Chun, Fernando Rodríguez De Fonseca, Absence of LPA1 Signaling Results in Defective Cortical Development, Cerebral Cortex, Volume 18, Issue 4, April 2008, Pages 938–950, https://doi.org/10.1093/cercor/bhm132
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026