RT Journal Article
T1 Update on the Epigenomic Implication of Embryo Cryopreservation Methods Applied in Assisted Reproductive Technologies With Potential Long-Term Health Effects
A1 Reyes Palomares, Arturo
A1 Rodriguez-Wallberg, Kenny
K1 Reproducción humana asistida
K1 Transferencia de embriones humanos
K1 Epigenética
AB Cryopreservation of embryos has become an efficient method in Assisted ReproductiveTechnologies (ART) and these methods are currently performed at nearly all fertility centersaround the globe. Cryopreservation of supernumerary embryos has contributed to anincrease in cumulative pregnancy rates and as a consequence, an increasing number ofchildren are being born through these techniques worldwide. However, long-term followup studies of children born through ART are scarce, and concerns about the long-termhealth effects on individuals conceived through ART have been raised. The relevantgenomic transformations that occur at the time cryopreservation is usually applied toembryos may have potential epigenetic risks. With advances in multi-omic single celltechnologies, new ways to assess the (epi)genomic status during early embryodevelopment have now become feasible. These novel strategies could provide arevolutionary opportunity to understand the actual impact of ART, but also may helpfuture developments aiming at increase both their efficiency and safety. Here we outlineinsights in current knowledge and research on the impact of cryopreservation on embryos,the possible consequences at epigenetic level and how emerging new high-throughputtechnologies can be used for their assessmen
PB Frontiers
YR 2022
FD 2022
LK https://hdl.handle.net/10630/44687
UL https://hdl.handle.net/10630/44687
LA eng
NO Reyes Palomares A and Rodriguez-Wallberg KA (2022) Update on the Epigenomic Implication of Embryo Cryopreservation Methods Applied in Assisted Reproductive Technologies With Potential LongTerm Health Effects. Front. Cell Dev. Biol. 10:881550. doi: 10.3389/fcell.2022.88155
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026