RT Journal Article
T1 Recreational Drugs and the Risk of Hepatocellular Carcinoma
A1 Pinazo-Bandera, José M.
A1 García-Cortés, Miren
A1 Segovia-Zafra, Antonio
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
K1 Drogas
AB Hepatocellular carcinoma represents an important contributor to the global cancer-related burden, and liver cirrhosis is the main risk factor for its development. Conventional or illegal drug consumption is a potential but infrequent cause of cirrhosis. However, the causal relationship between recreational drugs and the risk of developing liver cancer has not been studied in detail thus far. The aim of this review is to synthesize the available published evidence on legal and illegal recreational drug use and the risk of hepatocellular carcinoma and other liver tumors. Expanding our knowledge about the contributions of these substances to the appearance of liver cancers is important for combatting this preventable cause of cancer.AbstractRecreational or aesthetic drug use is a distinctive behavior of humans, principally attested in the last century. It is known that recreational and illegal drugs are major contributors to the universal morbidity rate worldwide. Many of these substances have a well-established hepatotoxic potential, causing acute or chronic liver injury, liver fibrosis and cirrhosis, but their implications for hepatocellular carcinoma or other varieties of liver tumors are little known. In this article, we perform an extensive literature review, aiming to provide updated information about recreational drug use and the risk of developing liver tumors. Khat use and pyrrolizidine alkaloid consumption (present in some natural plants) have been linked to liver cirrhosis. Kava intake is associated with different liver tumors in animal models but not in humans. Cannabis’ potential to accelerate liver fibrosis in chronic hepatitis is controversial according to the existing data. Cigarette smoking is an important contributor to hepatocellular carcinoma, and anabolic androgen steroids are well-defined causes of a variety of liver cancers and other hepatic tumors. (...)
PB IOAP-MPDI
YR 2022
FD 2022-11-02
LK https://hdl.handle.net/10630/25878
UL https://hdl.handle.net/10630/25878
LA eng
NO Pinazo-Bandera, J.M.; García-Cortés, M.; Segovia-Zafra, A.; Lucena, M.I.; Andrade, R.J. Recreational Drugs and the Risk of Hepatocellular Carcinoma. Cancers 2022, 14, 5395. https://doi.org/10.3390/cancers14215395
NO This research was supported by grants from Instituto de Salud Carlos III, cofounded by the Fondo Europeo de Desarrollo Regional—FEDER (contract numbers: FIS 21_01248; PI18/00901; UMA18-FEDERJA-193). CIBEREHD is funded by the Instituto de Salud Carlos III (ISCIII). All authors are members of the COST ACTION “CA-17112”, Prospective European Drug-Induced Liver Injury Network, supported by COST (European Cooperation in Science and Technology), www.cost.eu. JMPB holds a Rio Hortega contract from ISCIII. ASZ holds a Jaume Bosch Training Action 2022 from CIBEREHD (ISCIII).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026