RT Conference Proceedings
T1 18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
A1 Vegas-Gómez, Laura
A1 Edwards III, George
A1 Hasan, Omar
A1 Gámez, Nazaret
A1 Schulz, Jonathan
A1 Soto, Claudio
A1 Schulz, Paul
A1 Moreno-González, Inés
K1 Alzheimer, Enfermedad de
K1 Tomografía de emisión
AB Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of beta-amyloid protein (Aβ) and the formation of intraneuronal neurofibrillary tangles (NFT) composed of hyperphosphorylated tau (ptau), along with neuroinflammation and neuronal loss that ultimately induces to noticeable cognitive impairments. Abnormal ptau leads to the formation of insoluble, beta-sheet rich amyloid aggregates in tauopathies such as AD. Positron emission tomography (PET) imaging is a promising avenue that may identify tau aggregates in vivo cross-sectionally and longitudinally in various dementia conditions. Methods: The goal of this study is to characterize the longitudinal assessment of the tau tracer 18F-THK5351 by in vivo tau PET imaging concomitantly to behavior and tau pathology by histology and biochemistry from 6 to 12 months of age in tau transgenic P301S mice, a mouse model of tauopathies. Results: Our results demonstrate an augmentation of overall gross brain tau pathology by in vivo PET imaging in P301S mice compared to age-matched wild-type (WT) animals accompanied by P301S-model associated pathological tau and phenotypic and behavioral deficits. Conclusions: This longitudinal study provides new insights on the relationship between imaging diagnostic tools, the in vivo neuropathological temporal pattern and the clinical signs observed in animal models of AD that could benefit early disease diagnosis.
PB Alzheimer disease & Parkinson disease Conference 2021
YR 2021
FD 2021
LK https://hdl.handle.net/10630/21291
UL https://hdl.handle.net/10630/21291
LA eng
NO This work was partially funded by Department of Defense Peer Reviewed Alzheimer’s Research Program Convergence Science. Research Award grant AZ160106 and Alzheimer’s Association New Investigator Research Grant NIRG-394284 to IMG.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026