RT Journal Article
T1 Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
A1 Bettinetti-Luque, Miriam
A1 Trujillo-Estrada, Laura Isabel
A1 García-Fuentes, Eduardo
A1 Andreo-López, Juana
A1 Sánchez-Varo, Raquel María
A1 Gómez-Mediavilla, Ángela
A1 López, Manuela G.
A1 Gutiérrez, Antonia
A1 Baglietto-Vargas, David
A1 Garrido-Sánchez, Lourdes
A1 García-Caballero, Melissa
K1 Tejido adiposo
K1 Alzheimer, Enfermedad de
K1 Amiloide
K1 Inflamación (Patología)
K1 Sistema cardiovascular - Enfermedades
AB Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the adipose tissue and the brain. However, the contribution of adipose tissue to the development of age-related diseases, including Alzheimer's disease, remains poorly defined. New studies suggest that the adipose tissue modulates brain function through a range of endogenous biologically active factors known as adipokines, which can cross the blood–brain barrier to reach the target areas in the brain or to regulate the function of the blood–brain barrier. In this review, we discuss the effects of several adipokines on the physiology of the blood–brain barrier, their contribution to the development of Alzheimer's disease and their therapeutic potential.
PB Wiley
YR 2023
FD 2023-09-01
LK https://hdl.handle.net/10630/27854
UL https://hdl.handle.net/10630/27854
LA eng
NO Bettinetti-Luque, M., Trujillo-Estrada, L., Garcia-Fuentes, E., Andreo-Lopez, J., Sanchez-Varo, R., Garrido-Sánchez, L., Gómez-Mediavilla, Á., López, M. G., Garcia-Caballero, M., Gutierrez, A., & Baglietto-Vargas, D. (2023). Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease. British Journal of Pharmacology, 1–39. https://doi.org/10.1111/bph.16243
NO Funding for open access charge; Universidad de Málaga / CBUAFunding information Ministry of Science and Innovation,Grant / Award Numbers:PDC2022-133809-I00, PID2021-125986OB-I00, PID2019-108911RA-100; Alzheimer's
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026