RT Journal Article
T1 Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function
A1 Moreno-Indias, Isabel
A1 Oliva Olivera, Wilfredo
A1 Omiste Romero, Antonio Jesús
A1 Castellano Castillo, Daniel
A1 Lhamyani, Said
A1 Camargo, Antonio
A1 Tinahones-Madueño, Francisco José
K1 Tejido adiposo
K1 Metabolismo - Alteraciones
AB Discordant phenotypes, metabolically healthy obese and unhealthy normal-weight individuals, are always interesting to provide important insights into the mechanistic link between adipose tissue dysfunction and associated metabolic alterations. Macrophages can release factors that impair the proper activity of the adipose tissue. Thus, studying subcutaneous and visceral adipose tissues, we investigated for the first time the differences in monocyte/macrophage infiltration, inflammation, and adipogenesis of normal-weight subjects who differed in their degree of metabolic syndrome. The study included 92 normal-weight subjects who differed in their degree of metabolic syndrome. Their anthropometric and biochemical parameters were measured. RNA from subcutaneous and visceral adipose tissues was isolated, and mRNA expression of monocyte/macrophage infiltration (CD68, CD33, ITGAM, CD163, EMR-1, CD206, MerTK, CD64, ITGAX), inflammation (IL-6, tumor necrosis factor alpha [TNFα], IL-10, IL-1b, CCL2, CCL3), and adipogenic and lipogenic capacity markers (PPARgamma, FABP4) were measured. Taken together, our data provide evidence of a different degree of macrophage infiltration between the adipose tissues, with a higher monocyte/macrophage infiltration in subcutaneous adipose tissue in metabolically unhealthy normal-weight subjects, whereas visceral adipose tissue remained almost unaffected. An increased macrophage infiltration of adipose tissue and its consequences, such as a decrease in adipogenesis function, may explain why both the obese and normal-weight subjects can develop metabolic diseases or remain healthy.
PB Elsevier
YR 2016
FD 2016-06
LK https://hdl.handle.net/10630/45647
UL https://hdl.handle.net/10630/45647
LA eng
NO Moreno-Indias I, Oliva-Olivera W, Omiste A, Castellano-Castillo D, Lhamyani S, Camargo A, Tinahones FJ. Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function. Transl Res. 2016 Jun;172:6-17.e3. doi: 10.1016/j.trsl.2016.01.002. Epub 2016 Jan 18. PMID: 26829067.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026