RT Journal Article
T1 Astrocytes: From the physiology to the disease.
A1 Trujillo-Estrada, Laura Isabel
A1 Gómez-Arboledas, Ángela
A1 Forner, Stefania
A1 Cadete Martini, Alessandra
A1 Gutiérrez-Pérez, Antonia
A1 Baglietto-Vargas, David
A1 LaFerla, Frank M
K1 Sistema nervioso - Degeneración
K1 Neuroglia
AB Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many of these functions are intrinsically related to neurodegeneration, allowing refocusing on the role of astrocytes in physiological and neurodegenerative states. Indeed, emerging evidence in the field indicates that abnormalities in the astrocytic function are involved in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD) and Amyotrophic Lateral Sclerosis (ALS). In the present review, we highlight the physiological role of astrocytes in the CNS, including their communication with other cells in the brain. Furthermore, we discuss exciting findings and novel experimental approaches that elucidate the role of astrocytes in multiple neurological disorders.
PB Betham Science
YR 2019
FD 2019
LK https://hdl.handle.net/10630/38345
UL https://hdl.handle.net/10630/38345
LA eng
NO Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, Baglietto-Vargas D, LaFerla FM. Astrocytes: From the physiology to the disease. Curr Alzheimer Res. 16(8):675-698. 2019.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/1974
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026