RT Journal Article
T1 Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach
A1 Mustieles, Vicente
A1 Fernández, Mariana
A1 Martin-Olmedo, Piedad
A1 Gonzalez Alzaga, Beatriz
A1 Fontalba-Navas, Andrés
A1 Hauser, Russ
A1 Olea, Nicolás
A1 Arrebola, Juan Pedro
K1 Síndrome metabólico
K1 Tejido adiposo
K1 Contaminantes persistentes
AB We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome (“metabolically compromised”) was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. The cross-sectional analysis was conducted in the initial cohort, while the 10-year longitudinal analysis was conducted in those 154 participants free of any of the somentioned metabolic diseases and classified as “metabolically healthy” at recruitment. Statistical analyses were performed using single and multi-pollutant approaches through logistic and Cox regression analyses with elasticnet penalty. After adjusting for confounders, β-hexachlorocyclohexane (β-HCH) and hexachlorobenzene (HCB) were independently associated with an increased risk of being metabolically compromised (unpenalized ORs = 1.17, 95% CI = 1.01–1.36 and 1.17, 95% CI = 0.99–1.38, respectively). Very similar results were found in the 10-year longitudinal analysis [HRs = 1.28, 95% CI = 1.01–1.61 (β-HCH); 1.26, 95% CI = 1.00–1.59 (HCB)] and were in line with those obtained using elastic net regression. Finally, when the arithmetic sum of both compounds was used as independent variable, risk estimates increased to OR = 1.25, 95% CI = 1.03–1.52and HR = 1.32, 95% CI = 1.02–1.70. Our results suggest that historical exposure to HCB and β-HCH is consistently associated with the risk of metabolic disorders, and that these POPs might be partly responsible for the morbidity risk traditionally attributed to age and obesity.
PB Elsevier
YR 2017
FD 2017
LK https://hdl.handle.net/10630/30284
UL https://hdl.handle.net/10630/30284
LA eng
NO Mustieles V, Fernández MF, Martin-Olmedo P, González-Alzaga B, Fontalba-Navas A, Hauser R, Olea N, Arrebola JP. Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach. Environ Int. 2017 Jul;104:48-57. doi:10.1016/j.envint.2017.04.002
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026