RT Journal Article
T1 Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
A1 DeDiego, Marta L.
A1 Nieto-Torres, Jose Luis
A1 Regla-Nava, Jose Angel
A1 Jimenez-Guardeño, Jose Manuel
A1 Fernandez-Delgado, Raul
A1 Fett, Craig
A1 Castaño-Rodriguez, Carlos
A1 Perlman, Stanley
A1 Enjuanes, Luis
K1 Virus
K1 Coronavirus
K1 COVID-19
K1 Virología
AB Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated in several animal model systems. Here, we show that absence of the E protein resulted in reduced expression of proinflammatory cytokines, decreased numbers of neutrophils in lung infiltrates, diminished lung pathology, and increased mouse survival, suggesting that lung inflammation contributed to SARS-CoV virulence. Further, infection with SARS-CoV-ΔE resulted in decreased activation of NF-κB compared to levels for the wild-type virus. Most important, treatment with drugs that inhibited NF-κB activation led to a reduction in inflammation and lung pathology in both SARS-CoV-infected cultured cells and mice and significantly increased mouse survival after SARS-CoV infection. These data indicated that activation of the NF-κB signaling pathway represents a major contribution to the inflammation induced after SARS-CoV infection and that NF-κB inhibitors are promising antivirals in infections caused by SARS-CoV and potentially other pathogenic human coronaviruses.
PB ASM Journals
YR 2014
FD 2014
LK https://hdl.handle.net/10630/34244
UL https://hdl.handle.net/10630/34244
LA eng
NO DeDiego ML, Nieto-Torres JL, Regla-Nava JA, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodriguez C, Perlman S, Enjuanes L.2014.Inhibition of NF-κB-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival. J Virol88:.https://doi.org/10.1128/jvi.02576-13
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026