RT Journal Article
T1 Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions.
A1 González-García, Marta
A1 Carrillo-Franco, Laura
A1 Morales-Luque, Carmen
A1 Ponce-Velasco, Marina
A1 Gago-Calderón, Belén
A1 Dawid-Milner, Marc Stefan
A1 López-González, Manuel Víctor
K1 Laringe
K1 Neuronas motoras
AB To assess the possible interactions between the dorsolateral Periaqueductal Gray matter (dlPAG) and the laryngeal motor neurons of the nucleus Ambiguus (nA), we have examined the pattern of double staining c-Fos/FoxP2 protein immunoreactivity (c-Fos-ir/Fox-P2-ir) and Tyrosine Hydroxylase (TH) throughout the rostro-caudal extent of nA in spontaneously breathing anaesthetised male Sprague–Dawley rats during dlPAG electrical stimulation. Activation of the dlPAG elicited a selective increase in c-Fos-ir with an ipsilateral predominance in the somatas of the loose (p<0.05) and compact formation (p<0.01) within the nA and confirm the expression of FoxP2 bilaterally in all the domains within the nA. A second group of experiments was made to examine the importance of the dlPAG in modulating the laryngeal response evoked after electrical or chemical (glutamate) dlPAG stimulations. Both electrical and chemical stmulations evoked a significant decrease of laryngeal resistance (subglottal pressure) (p<0.001) accompanied with an increase in respiratory rate together with a pressor and tachycardic response. The results of our study contribute with new data on the role of the mesencephalic neuronal circuits in the control mechanisms of subglottic pressure and laryngeal activity.
PB Springer
YR 2024
FD 2024
LK https://hdl.handle.net/10630/31614
UL https://hdl.handle.net/10630/31614
LA eng
NO González-García, M., Carrillo-Franco, L., Morales-Luque, C. et al. Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions. Pflugers Arch - Eur J Physiol (2024). https://doi.org/10.1007/s00424-024-02976-3
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026