RT Journal Article
T1 Effects of GLP-1 receptor agonists on neurological complications of diabetes
A1 García-Casares, Natalia
A1 González-González, Guillermo
A1 De-la-Cruz-Cosme, Carlos
A1 Garzón-Maldonado, Francisco Javier
A1 De-Rojas-Leal, Carmen
A1 Ariza-Corbo, María José
A1 Narváez-Peláez, Manuel
A1 Barbancho-Fernández, Miguel Ángel
A1 García-Arnés, Juan Antonio
A1 Tinahones-Madueño, Francisco José
K1 Alzheimer, Enfermedad de
K1 Corazón - Enfermedades
AB Emerging evidence suggests that treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) could be an interesting treatment strategy to reduce neurological complications such as stroke, cognitive impairment, and peripheral neuropathy. We performed a systematic review to examine the evidence concerning the effects of GLP-1 RAs on neurological complications of diabetes. The databases used were Pubmed, Scopus and Cochrane. We selected clinical trials which analysed the effect of GLP-1 RAs on stroke, cognitive impairment, and peripheral neuropathy. We found a total of 19 studies: 8 studies include stroke or major cardiovascular events, 7 involve cognitive impairment and 4 include peripheral neuropathy. Semaglutide subcutaneous and dulaglutide reduced stroke cases. Liraglutide, albiglutide, oral semaglutide and efpeglenatide, were not shown to reduce the number of strokes but did reduce major cardiovascular events. Exenatide, dulaglutide and liraglutide improved general cognition but no significant effect on diabetic peripheral neuropathy has been reported with GLP-1 RAs. GLP-1 RAs are promising drugs that seem to be useful in the reduction of some neurological complications of diabetes. However, more studies are needed
PB Springer
YR 2023
FD 2023
LK https://hdl.handle.net/10630/26927
UL https://hdl.handle.net/10630/26927
LA eng
NO García-Casares, N., González-González, G., de la Cruz-Cosme, C. et al. Effects of GLP-1 receptor agonists on neurological complications of diabetes. Rev Endocr Metab Disord (2023). https://doi.org/10.1007/s11154-023-09807-3
NO This work was supported by the Instituto de Salud Carlos III (PI19/01375) co-financed with FEDER programme fund.Funding for open access publishing: Universidad Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026