RT Journal Article
T1 Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
A1 Mates-Sánchez, José Manuel
A1 di Paola, Floriana J.
A1 Campos-Sandoval, José Ángel
A1 Mazurek, Sybille
A1 Márquez-Gómez, Javier
K1 Cáncer
AB Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy,biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine isalso a signaling molecule involved in essential pathways regulated by oncogenes and tumor suppressor factors.Glutaminase isoenzymes are critical proteins to control glutaminolysis, a key metabolic pathway for cell proliferationand survival that directs neoplasms’ fate. Adaptive glutamine metabolism can be altered by differentmetabolic therapies, including the use of specific allosteric inhibitors of glutaminase that can evoke synergisticeffects for the therapy of cancer patients. We also review other clinical applications of in vivo assessment ofglutaminolysis by metabolomic approaches, including diagnosis and monitoring of cancer.
PB Elsevier
YR 2020
FD 2020-02
LK https://hdl.handle.net/10630/32822
UL https://hdl.handle.net/10630/32822
LA eng
NO José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez, Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer, Seminars in Cell & Developmental Biology, Volume 98, 2020, Pages 34-43, ISSN 1084-9521, https://doi.org/10.1016/j.semcdb.2019.05.012. (https://www.sciencedirect.com/science/article/pii/S1084952119300734)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026