RT Journal Article
T1 Avian embryonic coronary arterio-venous pattering involves the contribution of different endothelial and endocardial cell populations
A1 Palmquist-Gomes, Paul
A1 Pérez-Pomares, José María
A1 Guadix-Domínguez, Juan Antonio
K1 Circulación coronaria
K1 Aves - Embriología
AB Background: Coronary vasculature irrigates the myocardium and is crucial to late embryonic and adult heart function. Despitethe developmental significance and clinical relevance of these blood vessels, the embryonic origin and the cellular and molec-ular mechanisms that regulate coronary arterio-venous patterning are not known in detail. In this study, we have used theavian embryo to dissect the ontogenetic origin and morphogenesis of coronary vasculature. Results: We show that sinusvenosus endocardial sprouts and proepicardial angioblasts pioneer coronary vascular formation, invading the developingheart simultaneously. We also report that avian ventricular endocardium has the potential to contribute to coronary vessels,and describe the incorporation of cardiac distal outflow tract endothelial cells to the peritruncal endothelial plexus to partici-pate in coronary vascular formation. Finally, our findings indicate that large sinus venosus-independent sections of the form-ing coronary vasculature develop without connection to the systemic circulation and that coronary arterio-venous shuntsform a few hours before peritruncal arterial endothelium connects to the aortic root. Conclusions: Embryonic coronary vascu-lature is a developmental mosaic, formed by the integration of vascular cells from, at least, four different embryological ori-gins, which assemble in a coordinated manner to complete coronary vascular development.
PB Wiley
YR 2017
FD 2017-12-11
LK https://hdl.handle.net/10630/45400
UL https://hdl.handle.net/10630/45400
LA eng
NO Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM. Avian embryonic coronary arterio-venous patterning involves the contribution of different endothelial and endocardial cell populations. Developmental Dynamics. 2018;247(5):686–698. doi:10.1002/dvdy.24610
NO Adjunto la versión del manuscrito aceptado, sin paginación.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 feb 2026